Evidence map›Paper›PMID 40346872›Full record

ArticleAnnals of the New York Academy of Sciences2025

The 5D indicators of suicide risk in older adults who are lonely.

Kimberly A Van Orden, April Buttaccio, Yeates Conwell

Abstract read
In one paragraph

Article in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kimberly A Van OrdenDepartment of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-9439-401X
April ButtaccioDepartment of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.
Yeates ConwellDepartment of Psychiatry, University of Rochester Medical Center, Rochester, New York, USA.

Funding

The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
U24 NEW Brain Aging Diversity SupplementU24AG072701 · NIA · UNIVERSITY OF ROCHESTER · PI CONWELL, YEATES, LIN, FENG VANKEE · 2021 to 2024
$2.6M
The Getting Active Project (GAP): A Randomized Trial of Volunteering to Reduce Loneliness in Later LifeR01AG054457 · NIA · UNIVERSITY OF ROCHESTER · PI VAN ORDEN, KIMBERLY ALLISON · 2017 to 2021
$2.3M
Brain and Behavioral Mechanisms Linking Loneliness and Social Isolation with Accelerated Cognitive Aging and Alzheimer's Disease and Related DementiasK24AG084885 · NIA · UNIVERSITY OF ROCHESTER · PI Kimberly Allison Van Orden · 2024 to 2026
$493k
NCATS NIH HHS UL1 TR002001NCATS NIH HHS UL1TR002001NIA NIH HHS K24 AG084885NIA NIH HHS R01 AG054457NIA NIH HHS R01AG054457NIA NIH HHS U24 AG072701NIA NIH HHS U24AG072701
6 · The paper itself

Abstract

Loneliness is associated with suicide ideation, attempts, and deaths in later life. The objective of this study is to describe characteristics of suicide risk among older adults who report clinically significant loneliness grounded in our conceptual model of the 5Ds of late life suicide. Our sample comprises 291 adults aged 60 years and older who screened positive for loneliness (UCLA 3-Item Loneliness Scale score of 6 and above) and subsequently completed baseline eligibility interviews for a clinical trial. Interviews obtained information on loneliness severity, suicide ideation, and the 5Ds of late life suicide: (1) depression (PROMIS depression), (2) deadly means (firearms access), (3) disease (number of chronic conditions), (4) disconnection (objective disconnection, Lubben Social Network Scale; subjective disconnection, UCLA Loneliness Scale), and (5) disability (World Health Organization Disability Assessment Schedule). Subjects demonstrated a high frequency of characteristics associated with suicide risk, with the most common presentation (38%) being the presence of 3Ds-subjective disconnection (loneliness), multimorbidity, and disability. While few subjects presented with only subjective disconnection (loneliness), there was diversity in which other Ds were present and in which combination, suggesting heterogeneous presentations. Upstream suicide prevention efforts could target older adults with loneliness to reach a population with numerous compounding indicators of risk.

Indexed as

LonelinessSuicideAgedAged, 80 and overDepressionFemaleHumansMaleMiddle AgedRisk FactorsSuicidal Ideationbiopsychosocialgeriatricslonelinesssocial connectionsocial isolation

Identifiers

PMID40346872
PMCPMC12221791

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.