ArticleThe Laryngoscope2025
Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis.
Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Meta-Analysis and Systematic Review of Immune Checkpoint Expression in Predicting the Risk of Malignant Transformation in Oral Potentially Malignant Disorders.International dental journal · 2026Pooled it
- Beyond Clinicopathological Criteria: A Practical Management Framework for Oral Lichen Planus.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Malignant transformation rate of oral precancerous disorders to oral cancer: systematic review and meta-analysis of the current evidence.Frontiers in oral health · 2025Pooled it
- Chili Pepper Flavourants in "Heat" and "Unflavoured" Oral Nicotine Pouches Marketed in the United States.bioRxiv : the preprint server for biology · 2026Article
- In Reference to Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis.The Laryngoscope · 2026Article
- Preparedness of dental interns to identify oral potentially malignant disorders and oral cancer: a multi‑state cross‑sectional survey in India.BMC oral health · 2026Article
- Computational pathology-based artificial intelligence platform for the identification of common oral potentially malignant disorders.BMC oral health · 2026Article
- Transcriptomic atlas of premalignant oral squamous cell carcinoma in an aging mouse model reveals an enhanced immune response and dysregulation of head and neck tissue stem cells.bioRxiv : the preprint server for biology · 2026Article
- Clinical Applications and Diagnostic Performance of Adjunctive Light-Based Optical Technologies in Oral Potentially Malignant Disorders and Squamous Cell Carcinoma: A Systematic Review.Journal of clinical medicine · 2026Review
- Evaluating patients with oral leukoplakia in smokers versus non-smokers: A clinico-histopathological study.Bioinformation · 2026Article
- Diagnostic treatment modalities premalignant oral lesions oral cancer progression impact: Comparative study.Bioinformation · 2026Article
- Malignant Transformation Rate of Oral Premalignant Disorders: A Large Database Analysis.The Laryngoscope · 2025Article
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3 authors.
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Abstract
objectivesOral leukoplakia (OL), oral lichen planus (OLP), and oral submucous fibrosis (OSF) are precancerous lesions known to progress to oral squamous cell carcinoma (OSCC). The transformation rates to OSCC are controversial and have been based on small, heterogeneous, single-institution studies. We present the largest study to date looking at the malignant transformation rates of these oral premalignant disorders (OPMD).
methodsWe conducted a retrospective cohort study within the TriNetX database. Patients aged ≥ 18 with a diagnosis of OL, OLP, and OSF between 2008 and 2018 were included, allowing for up to 5 years of follow-up. The primary outcome was the 5-year rate of OSCC transformation compared to a control cohort. Secondary outcomes included treatment pathways and survival. Descriptive and comparative statistics were conducted using TriNetX software.
resultsTotally, 59,204 patients with diagnosed OL, OLP, or OSF were included. The average age of all included patients was 55.8 ± 14.1; the majority were female (n = 31,805, 53.7%) and white (n = 33,867, 57.2%). Rates of nicotine and alcohol dependence were 8.7% and 2.8%, respectively. The 5-year malignant transformation rates of OL, OLP, and OSF were 15.6%, 1.4%, and 18.6% (p < 0.01 compared to control), with an overall malignant transformation rate of 6.2% (p < 0.01 compared to control). The 5-year Kaplan-Meier survival probability was 94.3%.
conclusionsOur results indicate the rates at which patients with OPMD (OL, OLP, and OSF) progress to OSCC are higher than previously reported. Transformation rates for OL and OSF in particular underscore the need for close monitoring and prompt treatment to avoid malignant transformation. LEVEL OF EVIDENCE: Retrospective cohort study-Level 3.
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