Evidence map›Paper›PMID 40346826›Full record

ReviewJournal of investigative medicine high impact case reports

Brain Metastasis as the Initial Presentation of Carcinoid Tumor: Case Report and Literature Review.

Qusai A Alsalah, Taha Z Makhlouf, Donya Y Alqam, Maen HajMohammad, Ahmad G Hammouri, Marwan Qubaja, Bashir Abu Aqeel

Abstract readCase ReportsReview
In one paragraph

Review in Journal of investigative medicine high impact case reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. IASLC Update on Classification of Pulmonary Neuroendocrine Neoplasms.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qusai A AlsalahPalestine Polytechnic University, Hebron, Palestine.ORCID 0009-0009-9785-3205
Taha Z MakhloufPalestine Polytechnic University, Hebron, Palestine.ORCID 0009-0009-9578-1105
Donya Y AlqamPalestine Polytechnic University, Hebron, Palestine.
Maen HajMohammadAugusta Victoria Hospital, Jerusalem, Palestine.
Ahmad G HammouriAl-Ahli Hospital, Hebron, Palestine.
Marwan QubajaAugusta Victoria Hospital, Jerusalem, Palestine.
Bashir Abu AqeelAugusta Victoria Hospital, Jerusalem, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroendocrine neoplasms of the lung include neuroendocrine carcinomas and neuroendocrine tumors (NETs). NETs are also known as carcinoid tumors (CaTs), which are categorized as typical carcinoid and atypical carcinoid (AC). Pulmonary CaTs often metastasize to various sites, including regional lymph nodes, lungs, liver, and bone; however, metastasis to the brain is relatively rare. It is even rarer for patients with CaTs to present with signs of brain metastasis initially. We report the case of a 50-year-old female patient who initially presented with neurological symptoms and magnetic resonance imaging findings suggestive of multiple sclerosis. Despite initial treatment for multiple sclerosis, further evaluation uncovered a rare case of bronchopulmonary AC tumor metastasis to the brain. This case highlights the importance of considering metastatic disease in patients presenting with atypical neurological symptoms, especially when initial management fails to yield expected outcomes. Our literature review revealed 7 cases of CaTs initially presenting with brain metastases, with our patient being the youngest among all published cases.

Indexed as

Brain NeoplasmsCarcinoid TumorLung NeoplasmsFemaleHumansMagnetic Resonance ImagingMiddle AgedMultiple Sclerosisbrain metastasiscarcinoidmultiple sclerosisneuroendocrine neoplasmsradiotherapy

Identifiers

PMID40346826
PMCPMC12065991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.