Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18.
Emelie Backman, Remigius Gröning, Alicia Lind, Christoffer Granvik, Hinnerk Eilers, Anna Lange, Clas Ahlm, Sara Cajander, Mattias N E Forsell, Johan Normark and 1 more
Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Emelie BackmanDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Remigius GröningDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Alicia LindUmeå Centre for Microbial Research (UCMR), Umeå University, Umeå, Sweden.ORCID 0000-0003-0309-1852
Christoffer GranvikDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.ORCID 0009-0001-5257-8109
Hinnerk EilersLaboratory Medicine, Region Västerbotten, Norrland University Hospital, Umeå, Sweden.
Anna LangeDepartment of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Clas AhlmDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Sara CajanderDepartment of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Mattias N E ForsellDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Johan NormarkDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Constantin F UrbanDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.ORCID 0000-0003-1438-1134
Funding
C.A. from SciLifeLab, National COVID-19 Research Program VC-2020-0015C.F.U. from VR 2020-01764C.F.U. from VR 2022-00850E.B. from J. C. Kempes Minnes Stipendiefond;M.F. from VR consolidator 2020-06235Region Västerbotten (RV) 941762Region Västerbotten (RV) 981856Region Västerbotten (RV) 996165S.C. from Regional Research Council Mid Sweden and from Nyckelfonden Örebro OLL-938628S.C. from Regional Research Council Mid Sweden and from Nyckelfonden Örebro OLL-961416S.C. from Regional Research Council Mid Sweden and from Nyckelfonden Örebro RFR-940474S.C. from Regional Research Council Mid Sweden and from Nyckelfonden Örebro RFR-968856Umeå University and RV 938855via Knut & Alice Wallenberg Foundation, Swedish Heart-Lung Foundation 20200325via Knut & Alice Wallenberg Foundation, Swedish Heart-Lung Foundation 202100789via Knut & Alice Wallenberg Foundation, Swedish Heart-Lung Foundation 20220325
6 · The paper itself
Abstract
Severe COVID-19 disease is accompanied by high plasma levels of proinflammatory, prothrombotic NETs, and NET-inducing cytokine IL-18. We found that both, IL-18 and NETs, are elevated in men with severe disease, but not in women of the same category. Our findings warrant further investigation of sex-related differences in SARS-CoV-2 infection.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Elevated Plasma Levels of NET Components in Men with Severe COVID-19 Correlates to Increased Amounts of IL-18. · full record | OpenQuestion