ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
High rates of diagnostic discordance and co-pathology: Insights into PSP from the NACC dataset.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism.Nature medicine · 2026Article
- Comorbid pathologies and their impact on progressive supranuclear palsy: current view.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Cognitive impairment on the Alzheimer's Disease Centers' Uniform Data Set Version 3 Neuropsychological Test Battery in a Peruvian population with progressive supranuclear palsy.Arquivos de neuro-psiquiatria · 2026Article
- Amyloid and Tau Co-pathology in Parkinson Disease and Atypical Parkinsonism.Current neurology and neuroscience reports · 2026Review
- Dementia with lewy bodies and Alzheimer´s Disease overlap syndrome with PSP-like phenotype caused by co-pathologies - a case report.Journal of neurology · 2026Article
- High rates of diagnostic discordance and co-pathology: Insights into PSP from the NACC dataset.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionClinical features associated with accurate clinico-pathologic correlation within cognitive-predominant progressive supranuclear palsy (PSP) presentations have not been extensively studied. We identified features affecting PSP diagnosis within the National Alzheimer's Coordinating Center (NACC) dataset, a cognitive/behavioral research database.
methodsAutopsied NACC participants with clinical or neuropathologic PSP diagnoses were categorized by diagnostic modality (Clinical-only, Neuropathology-only, both). Group differences in clinical, demographic, neuropsychologic, and neuropathologic features were assessed.
resultsOnly 38.8% of neuropathologically identified PSP had clinical PSP diagnosis while 63.5% of clinically identified PSP had PSP pathology. Neuropathology-only cases had fewer motor symptoms and better processing speed/executive functioning than the Clinical-Neuropathology group. Nearly 70% demonstrated co-neuropathologies including Alzheimer-type, Lewy body, and corticobasal degeneration pathologies. DISCUSSION: Within NACC, discordant clinical and neuropathologic PSP diagnoses highlight the heterogeneity of PSP presentation, possibly driven by reliance on "classic" ante mortem symptoms. Further studies should assess the impact of co-pathology on clinical neurodegenerative disease presentations. HIGHLIGHTS: A high rate of clinico-pathologic PSP diagnostic discordance is seen within NACC. Cases without clinical PSP diagnosis had fewer classic motor and cognitive symptoms. Isolated PSP neuropathology is uncommon, with nearly 70% showing co-neuropathology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.