ArticleEuropean journal of medical research2025
Prognostic impact of lymph node and surgical margin in patients with perihilar cholangiocarcinoma.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Comparative analysis of survival outcomes and prognostic factors between intrahepatic and extrahepatic cholangiocarcinoma after surgical resection: a propensity score-matched study based on the SEER database.Langenbeck's archives of surgery · 2026Article
- Case Report: Making room for radicality: balancing liver reserve and oncologic clearance in hilar cholangiocarcinoma through portal vein embolisation.Frontiers in surgery · 2026Article
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7 authors.
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Abstract
backgroundThe study aimed to assess the prognostic impact of lymph node (LN) metastasis combined with surgical margin status on the 5-year overall survival (OS) of patients after radical resection perihilar cholangiocarcinoma (PHCC).
methodsClinicopathological data of patients with PHCC who underwent curative resection between June 2014 and June 2022 were analyzed retrospectively. Cox regression analyses were performed to evaluate the risk factors for OS and LN metastasis. Kaplan-Meier method with log-rank test was performed for OS curves.
results71 patients were enrolled and the 5-year OS rate was 52.4%. Poor differentiation grade, R1/2 resection, and the presence of LN metastasis were the independent prognostic factors of poor OS. In patients without LN metastasis, the 5-year OS rate was significantly higher in patients with negative surgical margin than patients with positive surgical margin. In LN metastasis positive patients, a comparable 5-year OS rate was found between patients with and without positive surgical margin (P = 0.185).
conclusionsIn patients with curatively resected for PHCC, R1 resection margin does not influence OS in patients with LN metastasis even when radical resection was achieved. Consequently, the risk of highly invasive procedures aimed at achieving R0 margins should be judiciously weighed against potential morbidity risk in patients with LN metastasis, as aggressive surgical strategies may not translate to survival benefits.
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