ArticleBMC pulmonary medicine2025
Lactate to albumin ratio as a determinant of intensive care unit admission and mortality in hospitalized patients with community-acquired pneumonia.
Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07279519 (Predictive Value of the Clinical Frailty Scale, Katz ADL, and Admission Laboratory Markers for Postoperative ICU Mortality in Geriatric Patients), which is not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictive Value of the Clinical Frailty Scale, Katz ADL, and Admission Laboratory Markers for Postoperative ICU Mortality in Geriatric Patients: A Prospective Observational Study
Who cites it
10 citing papers in PubMed.
- Lactate to albumin ratio LAR predicts mortality in critically ill adults with asthma across two cohorts.Scientific reports · 2026Article
- Lactate-to-albumin ratio as an independent predictor of short- and long-term mortality in ICU patients with malignant tumors: A retrospective cohort study.Oncology letters · 2026Article
- Glycemic variability does not provide incremental prognostic value for in-hospital death in community-acquired pneumonia patients: conventional clinical variables dominate.BMC pulmonary medicine · 2026Article
- Walking ability as a prognostic indicator in elderly patients with community-acquired pneumonia: a retrospective multicenter study.BMC geriatrics · 2026Observational
- The relationship between lactate-to-albumin ratio and prognosis in patients with sepsis-induced cardiomyopathy: a retrospective cohort study.Scientific reports · 2026Article
- Association between lactate-to-albumin ratio and 30-day all-cause mortality in patients with acute pancreatitis-associated acute kidney injury.Scientific reports · 2026Article
- Prognostic Value of the National Early Warning Score Combined with Nutritional and Endothelial Stress Indices for Mortality Prediction in Critically Ill Patients with Pneumonia.Medicina (Kaunas, Lithuania) · 2026Article
- Lactate dehydrogenase-to-albumin ratio as a potential prognostic indicator in glucocorticoid-treated severe pneumonia: a multicenter retrospective study with external validation.Frontiers in immunology · 2026Article
- Synergistic impact of immuno-nutritional and hypoxia-metabolic disturbances on post-stroke epilepsy: a "Two-Hit" prediction model and web-based risk calculator.Frontiers in nutrition · 2026Article
- Septic Shock in Hematological Malignancies: Role of Artificial Intelligence in Predicting Outcomes.Current oncology (Toronto, Ont.) · 2025Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivePrevious studies have shown that the lactate/albumin ratio (LAR) can be a prognostic biomarker in intensive care unit (ICU) patients. However, the usefulness of LAR in predicting mortality and guiding intensive care unit admission in hospitalized patients due to community-acquired pneumonia (CAP) remains unclear. This study aims to evaluate the predictive value of the LAR compared to Pneumonia Severity Index (PSI), Confusion, urea, respiratory rate, blood pressure, 65 years or older (CURB-65), and quick-Sequential Organ Failure Assessment (q-SOFA) scores in determining the need for ICU admission and mortality among hospitalized patients with CAP.
methodsAdult patients diagnosed and hospitalized with community-acquired pneumonia between July 2021 and July 2023 were included. Patients' demographics, comorbidities, disease severity scores, laboratory findings at the admission and outcomes were recorded. Patients were grouped and compared according to admission place (ward or ICU).
resultsPSI, CURB-65, q-SOFA scores, and LAR were higher in ICU patients than in those admitted to the ward. Regarding the ICU admission, the AUC values for PSI, CURB-65, q-SOFA and LAR were 0.794 (95% CI: 0.737-0.843) (p < 0.001), 0.825 (95% CI: 0.771-0.870) (p < 0.001), 0.755 (0.690-0.813) (p < 0.001), and 0.749 (95% CI: 0.689-0.802) (p < 0.001), respectively. Regarding the mortality, the AUC values for PSI, CURB-65, q-SOFA, and LAR were 0.722 (95% CI: 0.661-0.778) (p < 0.001), 0.743 (95% CI: 0.683-0.797) (p < 0.001), 0.645 (0.575-0.711) (p: 0.02), 0.761 (95% CI: 0.702-0.814) (p < 0.001), respectively. There wasn't any difference detected in pairwise comparisons of ROC curves.
conclusionIn this study, LAR was found to be a good predictor of ICU admissions and mortality in hospitalized patients with CAP and was non-inferior to PSI, CURB-65, or q-SOFA scores.
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