Evidence map›Paper›PMID 40346508›Full record

ArticleBMC pulmonary medicine2025

Study on the correlation between oxidized low- density lipoprotein and oxidized high- density lipoprotein with type 2 diabetes complicated by pulmonary tuberculosis.

Jing Gui, Feng Wang, Chuang-Yue Hong, Yu Fu, Hui Yang, Yu-Mao Cai

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Article in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jing Gui *Department of Pathogenic Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen , Guangdong, 518000, China. guij80@163.com.
Feng Wang *Department of Pathogenic Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen , Guangdong, 518000, China.
Chuang-Yue Hong *Department of Pathogenic Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen , Guangdong, 518000, China.
Yu FuDepartment of Pathogenic Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen , Guangdong, 518000, China.
Hui YangDepartment of Pathogenic Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen , Guangdong, 518000, China.
Yu-Mao CaiDepartment of Pathogenic Laboratory, Shenzhen Center for Chronic Disease Control, Shenzhen , Guangdong, 518000, China.

Funding

the National Natural Science Foundation of China No.82373641
6 · The paper itself

Abstract

objectivesThis study aims to investigate the correlations between oxidized lipoproteins, specifically oxidized low-density lipoprotein (oxLDL) and oxidized high-density lipoprotein (oxHDL), and the comorbidities of T2DM and PTB (T2DM + PTB).

methodsThis prospective study included 360 cases from May 2022 to May 2023. The cohort consisted of 60 cases of pure hyperlipidemia, 100 cases of PTB, 100 cases of T2DM, and 100 cases of T2DM + PTB. Each of the PTB, T2DM, and T2DM + PTB groups was further subdivided into a normal lipid subgroup (40 cases) and a hyperlipidemia subgroup (60 cases). Additionally, 40 healthy individuals served as a control group. The age range of participants spanned from 40.8 ± 7.36 to 56.34 ± 11.52 years. Venous blood samples were collected from each group to measure levels of HbA1c, insulin (INS), fasting serum glucose (FSG), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, apolipoprotein A-I(ApoA I), apolipoprotein B(Apo B), oxidized low-density lipoprotein (oxLDL), and oxidized high-density lipoprotein (oxHDL). Multivariate logistic regression analysis assessed the association of oxLDL and oxHDL levels with PTB.

resultsThe levels of oxLDL and oxHDL in the pure hyperlipidemia group, PTB hyperlipidemia subgroup,T2DM hyperlipidemia subgroup, and T2DM + PTB hyperlipidemia subgroup were significantly elevated compared to those in the control group. Correlation analysis demonstrated a positive correlation between TG and LDL-C with oxLDL in the T2DM hyperlipidemia subgroup and the T2DM + PTB hyperlipidemia subgroup. TC and LDL-C were also positively correlated with oxLDL in the PTB hyperlipidemia subgroup. All hyperlipidemia groups exhibited a positive correlation between TG and oxHDL. Multivariate logistic regression analysis showed that oxLDL ≥2362U/L~<4724 U/L (more than 2 times higher than the control group) and oxHDL ≥ 26 μg/L (more than 4 times higher than the control group) were relative risk factors for PTB.

conclusionSignificantly elevated oxLDL and oxHDL levels may be risk factors for PTB and may influence the comorbidity of T2DM and PTB. Further evaluation of pathological levels with oxLDL levels exceeding twice the control group and oxHDL levels exceeding four times the control group is recommended.

Indexed as

Diabetes Mellitus, Type 2Lipoproteins, HDLLipoproteins, LDLTuberculosis, PulmonaryAdultBlood GlucoseCase-Control StudiesFemaleGlycated HemoglobinHumansHyperlipidemiasLogistic ModelsMaleMiddle AgedProspective StudiesTriglyceridesBlood GlucoseGlycated HemoglobinLipoproteins, HDLLipoproteins, LDLoxidized low density lipoproteinTriglyceridesBlood lipidOxidized high-density lipoproteinOxidized low-density lipoproteinPulmonary tuberculosisType 2 diabetes mellitus

Identifiers

PMID40346508
PMCPMC12065307

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.