Evidence map›Paper›PMID 40346443›Full record

ArticleMolecular neurobiology2025

Oral Supplementation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Can Prevent TBI-Induced Visual, Motor, and Emotional Deficits in Mice.

Koushik Mondal, Ashlyn A Gary, Anisha Dash, Nobel A Del Mar, Daniel J Stephenson, Charles E Chalfant, Anton Reiner, Barry Sears, Nawajes Mandal

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Koushik MondalDepartment of Ophthalmology, The University of Health Science Centre, 930 Madison Ave., Suite 718, Memphis, TN, 38163, USA.
Ashlyn A GaryMiller School of Medicine, University of Miami, Miami, FL, USA.
Anisha DashETSU Quillen College of Medicine, Mountain Home, Johnson City, TN, 37684, USA.
Nobel A Del MarDepartment of Ophthalmology, The University of Health Science Centre, 930 Madison Ave., Suite 718, Memphis, TN, 38163, USA.
Daniel J StephensonDepartments of Medicine and Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA.
Charles E ChalfantDepartments of Medicine and Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA.
Anton ReinerDepartment of Ophthalmology, The University of Health Science Centre, 930 Madison Ave., Suite 718, Memphis, TN, 38163, USA.
Barry SearsInflammation Research Foundation, Peabody, MA, 01960, USA.
Nawajes MandalDepartment of Ophthalmology, The University of Health Science Centre, 930 Madison Ave., Suite 718, Memphis, TN, 38163, USA. nmandal@uthsc.edu.

Funding

The roles of ceramide and its derivatives in A. phagocytophilum pathogenesisR01AI139072 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI CHARLES E. CHALFANT, Jason A Carlyon · 2018 to 2026
$5.7M
The role and mechanistic regulation of cPLA2alpha in eicosanoid biosynthesis and wound healingR01GM137394 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E., KORDULA, TOMASZ K · 2021 to 2024
$1.9M
Sphingolipids and their Impact in Corneal Wound HealingR01EY031316 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KARAMICHOS, DIMITRIOS, MANDAL, NAWAJES · 2020 to 2023
$1.8M
Sphingolipid Metabolism and Signaling in the RetinaR01EY022071 · NEI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI MANDAL, NAWAJES · 2012 to 2016
$1.8M
The role of ceramide kinase in mitophagyR01GM137578 · NIGMS · UNIVERSITY OF VIRGINIA · PI CHALFANT, CHARLES E. · 2020 to 2023
$1.3M
BLRD VA I01 BX001792BLRD VA I01 BX004893BLRD VA IK6 BX004603NEI NIH HHS EY022071NEI NIH HHS R01 EY022071NEI NIH HHS R01 EY031316NIAID NIH HHS R01 AI139072NIGMS NIH HHS R01 GM137394NIGMS NIH HHS R01 GM137578US Department of Defense ofce of the Congressionally Directed Medical Research Programs (CDMRP), Vision Research Program grant W81XWH-20-1-0900US Veterans' Administration Senior Research Career Scientist Award IK6BX004603US Veterans' Administration (VA Merit Review) BX001792US Veterans' Administration (VA Merit Review Award) I01BX004893
6 · The paper itself

Abstract

Traumatic brain injury (TBI) causes neuroinflammation and can generate long-term pathological consequences, including motor and visual impairments, cognitive deficits, and depression. In our previous study, we found that Fat1

Indexed as

Brain Injuries, TraumaticDepressionFatty Acids, Omega-3Motor DisordersVision DisordersAdministration, OralAnimalsBehavior, AnimalBrainDietary SupplementsElectroretinographyFemaleMaleMiceMice, Inbred C57BLMicrogliaFatty Acids, Omega-3Sphingomyelin PhosphodiesteraseCeramideEmotional deficitsN-3 PUFANeuroinflammationTraumatic brain injury (TBI)Visual deficits

Identifiers

PMID40346443
PMCPMC12367975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.