Evidence map›Paper›PMID 40346415›Full record

ArticlePharmaceutical research2025

Hispidulin Isolated from the Leaves of Clerodendrum inerme (L.) Gaertn Suppresses Trigeminovascular System Activation in a Rat Model Mimicking Migraine.

Pi-Chuan Fan, Ming Tatt Lee, Tzu-Hsuan Lai, Wei-Jan Huang, Lih-Chu Chiou

Abstract read
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In one paragraph

Article in Pharmaceutical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pi-Chuan FanDepartment of Pediatrics, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan. pcfan6@ntu.edu.tw.ORCID http://orcid.org/0000-0002-6974-971X
Ming Tatt LeeDepartment of Pharmacology Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Rd., Section 1, Taipei, 10051, Taiwan.
Tzu-Hsuan LaiDepartment of Pediatrics, National Taiwan University Hospital, Taipei, 10002, Taiwan.
Wei-Jan HuangDepartment of Pharmaceutical Sciences, School of Pharmacy, Taipei Medical University, Taipei, 110, Taiwan.
Lih-Chu ChiouDepartment of Pharmacology Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Rd., Section 1, Taipei, 10051, Taiwan. lcchiou@ntu.edu.tw.

Funding

E-Da Hospital 106-EDN20E-Da Hospital 108-EDN08Ministry of Education 107M4022-3Ministry of Higher Education, Malaysia FRGS/1/2021/SKK06/UCSI/02/4Ministry of Higher Education, Malaysia FRGS/1/2021/WAB13/UCSI/02/1National Health Research Institutes NHRI-EX113-11114NINational Science and Technology Council MOST 106-2314-B-002-195National Science and Technology Council MOST 107-2314-B-002-170National Science and Technology Council MOST 111-2314-B-002-214National Science and Technology Council NSCT 112-2320-B-002 -059National Science and Technology Council NSCT 113-2320-B-002 -001National Science and Technology Council NSCT 113-2320-B-002 -052National Taiwan University Hospital 113-S0099National Taiwan University Hospital NTUHNational Taiwan University Hospital NTUH 111-S0152National Taiwan University Hospital NTUH 112-S0206UCSI University REIG-FPS-2023/043
6 · The paper itself

Abstract

backgroundHispidulin (6-methoxy-4',5,7-trihydroxyflavone) is a flavonoid commonly found in various plant products, including the leaves of Clerodendrum inerme (L.) Gaertn (CI). While there's an abundance of literature describing the therapeutic effect of hispidulin and CI in oncological, immunological, and dermatological models, their effect on neuropsychiatric disorders is also of research interest.

objectiveThe previous reports on the neuroprotective and GABA

methodsIn the present study, we employed the intracisternal instillation of capsaicin in anesthetized rats to induce the activation of trigeminovascular system (TGVS), which mimics the histopathological hallmarks of migraine that include increased neuronal activation in the trigeminal cervical complex (TCC), calcitonin gene-related peptide (CGRP) immunoreactivity in the trigeminal ganglia (TG) and CGRP depletion in the dura mater.

resultsAdministration of hispidulin (4, 10, and 50 mg/kg, i.p.) significantly reduced all three TGVS activation parameters induced by i.c. capsaicin. However, pre-treatment of a selective antagonist for α6 subunit-containing GABA

conclusionTo the best of our knowledge, this is the first report on hispidulin's suppressive effect on preclinical model of migraine. Further studies are required to explore the mechanism(s) of the antimigraine effect of hispidulin. However, these findings could potentially guide future clinical studies of hispidulin, with the aim of improving human health.

Indexed as

ClerodendrumFlavonesMigraine DisordersAnimalsCalcitonin Gene-Related PeptideCapsaicinDisease Models, AnimalDura MaterMalePlant ExtractsPlant LeavesRatsRats, Sprague-DawleyTrigeminal GanglionCalcitonin Gene-Related PeptideCapsaicinFlavoneshispidulinPlant Extractscalcitonin gene-related peptidehispidulinmigrainetrigeminal gangliatrigeminovascular system

Identifiers

PMID40346415

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.