Evidence map›Paper›PMID 40346314›Full record

SynthesisEuropean journal of clinical pharmacology2025

Purine xanthine oxidase inhibitors are not conducive to the prognosis of chronic heart failure: a meta-analysis.

Lin Ye, Anyi Xu, Jianing Huang, Yeyuan Zhang, Jie Yao, Fang Wang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lin YeDepartment of Intensive Care Unit, Ningbo No. 2 Hospital, Haishu District, Northwest Street 41, Ningbo, 315010, Zhejiang, China.
Anyi XuThe First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jianing HuangSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yeyuan ZhangSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jie YaoSchool of Public Health, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Fang WangDepartment of Intensive Care Unit, Ningbo No. 2 Hospital, Haishu District, Northwest Street 41, Ningbo, 315010, Zhejiang, China. 15957481362@163.com.

Funding

The Project of Key disciplines at the college level of Ningbo No.2 Hospital 2023-Y06The Project of Ningbo Leading Medical & Health Discipline, China 2022-F16
6 · The paper itself

Abstract

backgroundAccording to previous studies, the efficacy of xanthine oxidase inhibitors (XOIs) in patients with chronic heart failure (CHF) is still controversial. Therefore, the purpose of this study was to investigate the efficacy of XOIs in patients with CHF.

methodsUp to July 2024, we searched PubMed, EMBASE, Medline, Web of Science, and Cochrane Library for studies on the efficacy of XOI in patients with CHF. The main results included all-cause mortality, cardiovascular (CV) mortality, and heart failure (HF) hospitalization rates. The results were evaluated by hazard ratio (HR) and 95% confidence interval (95% CI).

resultsA total of eight studies were included in this meta-analysis, of which five were cohort studies and three were randomized controlled trials (RCTs). The total sample size was 301,345. The experimental group was exposed to allopurinol or hydroxypurinol. The all-cause mortality (HR = 1.26, 95% CI 1.05-1.51, p = 0.013) and CV mortality (HR = 1.58, 95% CI 1.17-2.14, p = 0.03) in the experimental group were higher than those in the control group. In terms of HF hospitalization, there was no difference between both groups (HR = 1.21, p = 0.292). Subgroup analysis showed that the CV hospitalization rate of the experimental group was higher than that of the control group, regardless of frequency and dose levels. The all-cause mortality in the low-dose group was higher than that in the control group (HR = 1.39, p = 0.033). The CV mortality of the low-dose group (HR = 1.55, p = 0.006) and the prevalent group (HR = 1.50, p = 0.042) was higher than that of the control group.

conclusionPurine XOI exposure may be unfavorable for the prognosis of CHF patients and is affected by the frequency and dose of use.

Indexed as

Enzyme InhibitorsHeart FailureXanthine OxidaseAllopurinolChronic DiseaseHospitalizationHumansOxypurinolPrognosisRandomized Controlled Trials as TopicAllopurinolEnzyme InhibitorsOxypurinolXanthine OxidaseAllopurinolChronic heart failureOxypurinolPrognosisXanthine oxidase inhibitors

Identifiers

PMID40346314

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.