ArticleScientific reports2025
High-content screening (HCS) workflows for FAIR image data management with OMERO.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Data Management Workflow for FAIR Sharing of Bioimaging Datasets in Plasma Medicine.Scientific data · 2026Article
- FlowRoI: fast optical-flow-based Roi extraction for high-throughput immune cell image compression.Npj imaging · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-content screening (HCS) for bioimaging is a powerful approach to studying biological processes, enabling the acquisition of large amounts of images from biological samples. However, it generates massive amounts of metadata, making HCS experiments a unique data management challenge. This data includes images, reagents, protocols, analytic outputs, and phenotypes, all of which must be stored, linked, and made accessible to users, scientists, collaborators, and the broader community to ensure sharable results. This study showcases different approaches using Workflow Management Systems (WMS) to create reusable semi-automatic workflows for HCS bioimaging data management, leveraging the image data management platform OMERO. The three developed workflows demonstrate the transition from a local file-based storage system to an automated and agile image data management framework. These workflows facilitate the management of large amounts of data, reduce the risk of human error, and improve the efficiency and effectiveness of image data management. We illustrate how applying WMS to HCS data management enables us to consistently transfer images across different locations in a structured and reproducible manner, reducing the risk of errors and increasing data consistency and reproducibility. Furthermore, we suggest future research direction, including developing new workflows and integrating machine learning algorithms for automated image analysis. This study provides a blueprint for developing efficient and effective image data management systems for HCS experiments and demonstrates how different WMS approaches can be applied to create reusable, semi-automated workflows for HCS bioimaging data management using OMERO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.