Evidence map›Paper›PMID 40346113›Full record

Articlenpj aging2025

Wearable sleep recording augmented by artificial intelligence for Alzheimer's disease screening.

Elisabeth R M Heremans, Astrid Devulder, Pascal Borzée, Rik Vandenberghe, François-Laurent De Winter, Mathieu Vandenbulcke, Maarten Van Den Bossche, Bertien Buyse, Dries Testelmans, Wim Van Paesschen and 1 more

Abstract read
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elisabeth R M Heremans *STADIUS Center for Dynamical Systems, Signal Processing and Data Analytics-Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium.
Astrid Devulder *Laboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group, Leuven, Belgium.
Pascal BorzéeDepartment of Pulmonary Diseases, University Hospitals Leuven, Leuven, Belgium.
Rik VandenbergheDepartment of Neurology, University Hospitals Leuven, Leuven, Belgium.
François-Laurent De WinterNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group, Leuven, Belgium.
Mathieu VandenbulckeNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group, Leuven, Belgium.
Maarten Van Den BosscheNeuropsychiatry, Department of Neurosciences, Leuven Brain Institute, KU Leuven Biomedical Sciences Group, Leuven, Belgium.
Bertien BuyseDepartment of Pulmonary Diseases, University Hospitals Leuven, Leuven, Belgium.
Dries TestelmansDepartment of Pulmonary Diseases, University Hospitals Leuven, Leuven, Belgium.
Wim Van PaesschenLaboratory for Epilepsy Research, KU Leuven Biomedical Sciences Group, Leuven, Belgium.
Maarten De VosSTADIUS Center for Dynamical Systems, Signal Processing and Data Analytics-Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium. maarten.devos@kuleuven.be.

Funding

Fonds Wetenschappelijk Onderzoek 1SC2921NKU Leuven C24/18/097Vlaamse regering AI Research Program
6 · The paper itself

Abstract

The recent emergence of wearable devices will enable large scale remote brain monitoring. This study investigated whether multimodal wearable sleep recordings could help screening for Alzheimer's disease (AD). Measurements were acquired simultaneously from polysomnography and a wearable device, measuring electroencephalography (EEG) and accelerometry (ACM) in 67 elderly without cognitive symptoms and 35 AD patients. Sleep staging was performed using an AI model (SeqSleepNet), followed by feature extraction from hypnograms and physiological signals. Using these features, a multi-layer perceptron was trained for AD detection, with elastic net identifying key features. The wearable AD detection model achieved an accuracy of 0.90 (0.76 for prodromal AD). Single-channel EEG and ACM physiological features captured sufficient information for AD detection and outperformed the hypnogram features, highlighting these physiological features as promising discriminative markers for AD. We conclude that wearable sleep monitoring augmented by AI shows promise towards non-invasive screening for AD in the older population.

Identifiers

PMID40346113
PMCPMC12064732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.