Evidence map›Paper›PMID 40346065›Full record

ArticleNPJ Parkinson's disease2025

Protein-truncating variants in UQCRC1 are associated with Parkinson's disease: evidence from half-million people.

Xiaoxi Jing, Zongzhi Liu, Wenwen Li, Kaiyan Ma, Jiaxiang Zhang, Zeqi Yan, Shuo Zhang, Jiecong Lin, Junpeng Zhao, Ken K Ong and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Characterization of aMolecular genetics and metabolism reports · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaoxi Jing *Changping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Zongzhi Liu *Changping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Wenwen Li *Innovation Center for Neurological Disorders and Department of Neurology, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Kaiyan MaChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Jiaxiang ZhangChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Zeqi YanChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Shuo ZhangChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Jiecong LinChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Junpeng ZhaoChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China.
Ken K OngMRC Epidemiology Unit and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
John R B PerryMRC Epidemiology Unit and NIHR Cambridge Biomedical Research Centre, Wellcome-MRC Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Yajie ZhaoChangping Laboratory, Yard-28, Science Park Road, Changping District, Beijing, P. R. China. yajiezhao@cpl.ac.cn.

Funding

Medical Research Council MC_UU_00006/2Wellcome Trust
6 · The paper itself

Abstract

Recent studies have suggested a potential but inconsistent link between UQCRC1 and Parkinson's disease (PD). For the first time, we systematically investigated the association between non-synonymous variants in UQCRC1 and PD risk using data from the UK Biobank with half-million participants, which provide evidence supporting the role of UQCRC1 Protein-truncating variants (PTVs) in PD (P = 1.20 × 10

Identifiers

PMID40346065
PMCPMC12064775

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.