Evidence map›Paper›PMID 40345978›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2025

IL-21 Loading CaMnCO

Baihui Wang, Yuchan Xue, Yang Jia, Yuyao Duan, Dejun Li, Minghao Sui, Yuemin Feng, Le Wang, Han Ding, Xinyu Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Advances in integrating biomaterials with CAR-T cells for enhancing solid tumor therapy.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  5. IL-21 Loading CaMnCOSmall (Weinheim an der Bergstrasse, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Baihui WangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Yuchan XueDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Yang JiaDepartment of Thoracic Surgery, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Yuyao DuanReproductive Medical Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250012, P. R. China.
Dejun LiDepartment of ICU, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Minghao SuiDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Yuemin FengDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Le WangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Han DingDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Xinyu WangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Tianru ZhangDepartment of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Yanning SunUrology Department, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, P. R. China.
Huimin LiuDepartment of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Jianni QiDepartment of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.
Jiazhi DuanInstitute for Advanced Interdisciplinary Research, University of Jinan, Jinan, 250022, P. R. China.
Songbo ZhaoDepartment of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.ORCID 0009-0004-1843-4349
Qiang ZhuDepartment of Infectious Disease, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, P. R. China.

Funding

National Natural Science Foundation of China 82100641National Natural Science Foundation of China 82160124National Natural Science Foundation of China 82203658National Natural Science Foundation of China 82302067National Natural Science Foundation of China 82370618Natural Science Foundation of Shandong Province ZR2020QH265Natural Science Foundation of Shandong Province ZR2021QH074Natural Science Foundation of Shandong Province ZR2021QH276Natural Science Foundation of Shandong Province ZR2022MH281Natural Science Foundation of Shandong Province ZR2023QC179Natural Science Foundation of Shandong Province ZR2023QE146
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR)-T-cell therapy achieves considerable success in the treatment of malignant tumors, but clinical relapse due to the tumor microenvironment (TME) is very common. The TME of solid tumors is characterized by weak acidity, hypoxia, and elevated reactive oxygen species (ROS) levels, which collectively impair the function and persistence of infiltrating CAR-T cells. In this study, acid-sensitive responsive CaMnCO

Indexed as

CobaltImmunotherapyImmunotherapy, AdoptiveInterleukinsReceptors, Chimeric AntigenT-LymphocytesAnimalsCell Line, TumorHumansInterleukin-21MiceNanoparticlesTumor MicroenvironmentCobaltInterleukin-21InterleukinsReceptors, Chimeric AntigenCAR‐T cellhepatocellular carcinomaimmunoactivationtumor microenvironmentvitality backpacks

Identifiers

PMID40345978
PMCPMC12199124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.