Evidence map›Paper›PMID 40345900›Full record

ReviewTrends in microbiology2025

Advances in host-directed therapy for tuberculosis and HIV coinfection: enhancing immune responses.

Preena Prasanna, Bianca Herrera, Larry S Schlesinger, Mirko Paiardini, Riti Sharan

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Molecular signaling in coinfection: howFrontiers in immunology · 2026
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Preena PrasannaTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Bianca HerreraTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Larry S SchlesingerTexas Biomedical Research Institute, San Antonio, TX 78227, USA.
Mirko PaiardiniEmory National Primate Research Center, Emory University, Atlanta, GA, USA; Emory School of Medicine, Emory University, Atlanta, GA, USA.
Riti SharanTexas Biomedical Research Institute, San Antonio, TX 78227, USA. Electronic address: rsharan@txbiomed.org.

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI GIORDANO, THOMAS P · 2021 to 2025
$8.3M
Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
Single cell trancriptomics to identify LTBI reactivation markers in TB/HIV co-infectionR21AI170148 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2022 to 2023
$800k
Effect of IL-21 treatment concurrent to ART and 3HP in Mtb/SIV co-infectionR56AI184089 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2024 to 2024
$719k
Characterizing IL-22 driven chronic immune activation in HIV/TB co-pandemicK01OD031898 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SHARAN, RITI · 2021 to 2023
$567k
NIAID NIH HHS P30 AI161943NIAID NIH HHS P30 AI168386NIAID NIH HHS P30 AI168439NIAID NIH HHS R21 AI170148NIAID NIH HHS R56 AI184089NIH HHS K01 OD031898NIH HHS P51 OD011133
6 · The paper itself

Abstract

Tuberculosis (TB) and HIV coinfection present a significant global health challenge worldwide. While most individuals infected with Mycobacterium tuberculosis (Mtb) have clinically asymptomatic latent TB infection (LTBI), those with immunosuppressive conditions, such as HIV, are at higher risk for reactivation and disseminated TB. HIV exacerbates TB progression by impairing immune responses, particularly through the depletion of Mtb-specific CD4

Indexed as

CoinfectionHIV InfectionsTuberculosisCytokinesHumansImmune Checkpoint InhibitorsLatent TuberculosisMycobacterium tuberculosisCytokinesImmune Checkpoint Inhibitorscytokine modulatorsHDTimmune activationTB/HIV coinfection

Identifiers

PMID40345900
PMCPMC12758916

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.