Evidence map›Paper›PMID 40345856›Full record

ArticleInternational journal of cancer2025

Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors.

Xiaoyun Tang, Humayara Khan, Karolina Niewola-Staszkowska, Frank Wuest, David N Brindley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoyun TangCancer Research Institute of Northern Alberta, Edmonton, Alberta, Canada.
Humayara KhanCancer Research Institute of Northern Alberta, Edmonton, Alberta, Canada.
Karolina Niewola-StaszkowskaiOnctura, Geneva, Switzerland.
Frank WuestCancer Research Institute of Northern Alberta, Edmonton, Alberta, Canada.
David N BrindleyCancer Research Institute of Northern Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-2227-0020

Funding

CIHR PJT-169140MITACS
6 · The paper itself

Abstract

Tumor-associated fibrosis contributes to an immunosuppressive microenvironment that hinders effective anti-tumor immune responses. This study investigates the potential of IOA-289, a novel autotaxin (ATX) inhibitor, which blocks lysophosphatidate (LPA) production and signaling, in modulating fibrosis in breast tumors. Bioinformatic analysis of human breast tumors revealed a strong correlation between levels of LPA

Indexed as

Breast NeoplasmsMammary Neoplasms, ExperimentalPhosphoric Diester HydrolasesAnimalsCell Line, TumorFemaleFibrosisHumansLysophospholipase DLysophospholipidsMiceReceptors, Lysophosphatidic AcidTransforming Growth Factor beta1Tumor Microenvironmentlysophosphatidic acidLysophospholipase DLysophospholipidsPhosphoric Diester HydrolasesReceptors, Lysophosphatidic AcidTransforming Growth Factor beta1collagenDMEM  Dulbecco's Modified Eagle's MediumFBSC  Charcoal‐treated fetal bovine serumFBS fetal bovine serumfibroblastsfibronectinlysophosphatidic acidtransforming growth factor‐β

Identifiers

PMID40345856
PMCPMC12280849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.