Evidence map›Paper›PMID 40345834›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

The Molecular Substrates of Second-Order Conditioned Fear in the Basolateral Amygdala Complex.

Jessica Leake, Artur Shvetcov, Kelly J Clemens, Kelly Kershaw, R Frederick Westbrook, Nathan M Holmes

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jessica LeakeSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
Artur ShvetcovSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
Kelly J ClemensSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID 0000-0003-2709-218X
Kelly KershawSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
R Frederick WestbrookSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia.
Nathan M HolmesSchool of Psychology, University of New South Wales, Sydney, New South Wales 2052, Australia n.holmes@unsw.edu.au.ORCID 0000-0002-0592-2026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rats quickly learn to fear a stimulus (e.g., a light) that signals brief but painful footshock. The consolidation of this first-order conditioned fear requires transcription and translation of specific genes in the basolateral amygdala complex (BLA). Rats also learn to fear the associates of first-order conditioned stimuli, such as a sound paired with the already-conditioned light. The consolidation of this second-order conditioned fear also requires transcriptional processes in the BLA, but unlike consolidation of first-order fear, it is unaffected by BLA infusions of the protein synthesis inhibitor, cycloheximide. Accordingly, this study sought to identify genes/pathways that regulate second-order conditioned fear in male rats. It focused on the involvement of immediate early genes, as these can be transcribed in the presence of protein synthesis inhibitors. In Experiment 1, we used a principal components analysis of PCR data and found that second-order fear conditioning involves region- and time-specific changes in a network of genes including the immediate early genes

Indexed as

AmygdalaBasolateral Nuclear ComplexConditioning, ClassicalFearAnimalsBrain-Derived Neurotrophic FactorCycloheximideEarly Growth Response Protein 1MaleProtein Synthesis InhibitorsRatsRats, Sprague-DawleyBrain-Derived Neurotrophic FactorCycloheximideEarly Growth Response Protein 1Egr1 protein, ratProtein Synthesis Inhibitorsbasolateral amygdalabdnfegr1fear conditioningimmediate early genesrat

Identifiers

PMID40345834
PMCPMC12178287

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.