ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025
The Neurobiology of Cognitive Fatigue and Its Influence on Effort-Based Choice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of mental fatigue on lower-limb explosive power and anaerobic capacity: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.Biological psychiatry global open science · 2026Article
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Examining effects of effort and reward magnitude on effort-cost decision-making in people with major depressive disorder.Cognitive, affective & behavioral neuroscience · 2026Article
- Poststroke Fatigue: An Overlooked Barrier to Functional Recovery.Journal of the American Heart Association · 2026Article
- Multidimensional Determinants of Sexual Dysfunction in Multiple Sclerosis: Incremental Insights from a Hierarchical Model.Journal of clinical medicine · 2026Article
- Article
- Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder.medRxiv : the preprint server for health sciences · 2025Article
- Effects of Different Numbers of Trials on Saccadometry Test Results.Brain and behavior · 2025Article
- The Impact of Chronic Fatigue on Psychopathology in Outpatient Physiotherapy Patients.Musculoskeletal care · 2025Article
- Neural mechanisms underlying the effects of cognitive fatigue on physical effort-based choice.bioRxiv : the preprint server for biology · 2024Article
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3 authors.
Funding
Abstract
Feelings of cognitive fatigue emerge through repeated mental exertion and are ubiquitous in our daily lives. However, there is a limited understanding of the neurobiological mechanisms underlying the influence of cognitive fatigue on decisions to exert. We use functional magnetic resonance imaging while participants (18 females, 10 males) chose to exert effort for reward, before and after bouts of fatiguing cognitive exertion. We found that when participants became cognitively fatigued, they were more likely to choose to forgo higher levels of reward for more effort. We describe a mechanism by which signals related to cognitive exertion in the dorsolateral prefrontal cortex influence effort value computations, instantiated by the insula, thereby influencing an individual's decisions to exert while fatigued. Our results suggest that cognitive fatigue plays a critical role in decisions to exert effort and provides a mechanistic link through which information about cognitive state shapes effort-based choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.