Evidence map›Paper›PMID 40345741›Full record

ArticleJACC. Case reports2025

Epicardial Coronary Spasm in Left Anterior Descending Artery and Coronary Microvascular Spasm in Right Coronary Artery.

Takahiro Watanabe, Yoshihisa Kanaji, Eisuke Usui, Masahiro Hada, Tatsuhiro Nagamine, Hiroki Ueno, Mirei Setoguchi, Kodai Sayama, Hikaru Shimosato, Tsunekazu Kakuta

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Takahiro WatanabeDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Yoshihisa KanajiDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Eisuke UsuiDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Masahiro HadaDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Tatsuhiro NagamineDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Hiroki UenoDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Mirei SetoguchiDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Kodai SayamaDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Hikaru ShimosatoDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Tsunekazu KakutaDepartment of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan. Electronic address: kaz@joy.email.ne.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 71-year-old woman presented with rest angina. A spasm provocation test (SPT) using acetylcholine (Ach) confirmed epicardial coronary vasospasm in the left anterior descending artery (LAD) and coronary microvascular spasm (MVS) in the right coronary artery (RCA), according to current guidelines. After nitrate administration, coronary function tests (CFTs) with adenosine were conducted on the RCA at 30-minute intervals, demonstrating significant improvement in coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). This case was first diagnosed as vasospastic angina (VSA) involving the LAD, MVS in the RCA, normal coronary function in the LAD, and coronary microvascular dysfunction (CMD) in the RCA, highlighting regional differences in vascular reactivity and microvascular function in the same patients. The improvement in CFR and IMR during the second CFT suggests longer persistence of MVS, indicating that post-SPT functional testing may overestimate microvascular dysfunction due to lingering MVS, even after nitrate administration.

Indexed as

coronary microvascular dysfunctioncoronary vasospasmmicrovascular spasm

Identifiers

PMID40345741
PMCPMC12245419

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.