ArticleJournal of advanced research2026
SA supplementation during lactation promotes learning and memory by reducing H3K27me3 levels.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Early-Life High-Fat Diet Impairs Autophagy and Reduces GABANutrients · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSialic acid (SA) is an essential nutrient for brain development and cognition. Infants lack the capacity to synthesize sufficient SA independently, requiring reliance on maternal or exogenous sources. For early nutritional supplementation, elucidating how SA affects learning and memory is necessary.
objectivesThis study aimed to elucidate the critical time window for SA supplementation that best supports cognitive functions and hippocampal neural mechanisms.
methodsThe MWM experiment was conducted to elucidate the critical time window and dose of SA supplementation. Morphological and electrophysiological studies were used to observe the structural and functional responses of hippocampal neurons that are exposed to SA. RNA sequencing, Western Blot, immunofluorescence, and electrophysiology were used to screen and validate possible neural mechanisms.
resultsOur results show that SA supplementation during, but not after, the lactation period significantly improves learning and memory. SA promotes neurite outgrowth and increases synaptic transmission without affecting the intrinsic membrane properties of hippocampal CA1 neurons. The effect of SA on CA1 neuronal function is independent of the DG-CA3-CA1 loop. Also, long-term effects on synaptic plasticity are primarily due to intracellular epigenetic changes of H3K27me3 rather than direct binding of extracellular SA to membrane proteins. Consequently, our study indicates that decreased H3K27me3 promotes the glutamate-glutamine cycle under SA, thereby contributing to enhanced learning and memory.
conclusionConsequently, our study finds that decreased H3K27me3 promotes the glutamate-glutamine cycle under the influence of SA, thereby contributing to enhanced learning and memory. The potential implication of our findings is that SA in early life may contribute to the optimization of children's comprehensive cognitive function.
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