Evidence map›Paper›PMID 40345610›Full record

ArticleBiological psychiatry2025

Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study.

Annalisa Lella, Linda A Antonucci, Roberta Passiatore, Loredana Bellantuono, Pierluigi Selvaggi, Teresa Popolizio, Guido Di Sciascio, Alessandro Saponaro, Patrizia Ricci, Mario Altamura and 74 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

84 authors.

Annalisa LellaDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy.
Linda A AntonucciDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy.
Roberta PassiatoreDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland.
Loredana BellantuonoDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Istituto Nazionale di Fisica Nucleare, Bari, Italy.
Pierluigi SelvaggiDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy.
Teresa PopolizioNeuroradiology Unit, Scientific Institute for Research, Hospitalization and Health Care, San Giovanni Rotondo, Foggia, Italy.
Guido Di SciascioDepartment of Mental Health, Azienda Sanitaria Locale Bari, Bari, Italy.
Alessandro SaponaroDepartment of Mental Health, Azienda Sanitaria Locale Brindisi, Brindisi, Italy.
Patrizia RicciDepartment of Mental Health, Azienda Sanitaria Locale Barletta Andria Trani, Barletta-Andria-Trani, Italy.
Mario AltamuraDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
Giuseppe BlasiDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy.
Antonio RampinoDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy.
Chris VriendAmsterdam University Medical Center, Vrije Universiteit Amsterdam, Department of Psychiatry and Department of Anatomy and Neuroscience, Amsterdam, the Netherlands; Compulsivity, Impulsivity and Attention, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Vince D CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, Emory University, Atlanta, Georgia.
Kelly Rootes-MurdyTri-Institutional Center for Translational Research in Neuroimaging and Data Science, Georgia Institute of Technology, Georgia State University, Emory University, Atlanta, Georgia.
Aaron L GoldmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland.
Inmaculada BaezaDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic Barcelona, University of Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.
Josefina Castro-FornielesDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic Barcelona, University of Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.
Gisela SugranyesDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic Barcelona, University of Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.
Elena De la SernaDepartment of Child and Adolescent Psychiatry and Psychology, Institute of Neuroscience, Hospital Clínic Barcelona, University of Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental, Barcelona, Spain.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos III, Barcelona, Spain.
Mar Fatjó-VilasFIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos III, Barcelona, Spain.
Raymond SalvadorFIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos III, Barcelona, Spain.
Andriana KarukFIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos III, Barcelona, Spain.
Paola Fuentes-ClaramonteFIDMAG Germanes Hospitalàries Research Foundation, Centro de Investigación Biomédica en Red de Salud Mental Instituto de Salud Carlos III, Barcelona, Spain.
David C GlahnDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut.
Amanda L RodrigueDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine at University of Texas Rio Grande Valley, Brownsville, Texas.
Lei WangDepartment of Psychiatry and Behavioral Health, Neuroscience, Ohio State University Wexner Medical Center, Columbus, Ohio.
Taeyoung LeeDepartment of Psychiatry, Kyungpook National University School of Medicine, Daegu, South Korea; Department of Psychiatry, Kyungpook National University Hospital, Daegu, South Korea; Department of Biomedical Engineering, Graduate School of Biomedical Sciences and Engineering, Hanyang University, Seoul, South Korea.
Karolin E EinenkelSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Saskia HamersSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany; Division of Clinical Psychology and Sexual Medicine, Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
Adrian PredaDepartment of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California.
Young-Chul ChungDepartment of Psychiatry, Jeonbuk National University, Medical School, Jeonju, South Korea; Department of Psychiatry, Jeonbuk National University Hospital, Jeonju, Korea; Research Institute of Clinical Medicine of Jeonbuk National University-, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
Soyolsaikhan OdkhuuDepartment of Psychiatry, Jeonbuk National University, Medical School, Jeonju, South Korea; Research Institute of Clinical Medicine of Jeonbuk National University-, Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Korea.
Corentin ValléeDepartment of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
Paola DazzanDepartment of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; National Institute for Health and Care Research Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, United Kingdom.
Machteld MarcelisDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.
Stijn MichielseDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Maastricht University, Maastricht, the Netherlands.
Katharina BroschDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany; Institute of Behavioral Science, Feinstein Institutes for Medical Research, Manhasset, New York.
Frederike SteinDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Igor NenadićDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Benjamin StraubeDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Florian Thomas-OdenthalDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Tilo KircherDepartment of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
Sean CarruthersCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, Victoria, Australia.
Susan L RossellCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, Victoria, Australia.
Phillip J SumnerCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, Victoria, Australia.
Tamsyn E Van RheenenCentre for Mental Health and Brain Sciences, Swinburne University, Melbourne, Victoria, Australia; Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
Caroline DemroDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota.
Ian S RamsayDepartment of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota.
Scott R SponheimMinneapolis Veterans Affairs Health Care System, Minneapolis, Minnesota; Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota.
Rebekka LencerInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Susanne MeinertInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Tim HahnInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Udo DannlowskiInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Dominik GrotegerdInstitute for Translational Psychiatry, University of Münster, Münster, Germany.
Mariateresa CiccarelliSection of Psychiatry, Department of Neuroscience, Reproductive Sciences, and Dentistry, University School of Medicine Federico II, Naples, Italy.
Felice IasevoliSection of Psychiatry, Department of Neuroscience, Reproductive Sciences, and Dentistry, University School of Medicine Federico II, Naples, Italy.
Giuseppe PontilloDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy; Department of Electrical Engineering and Information Technology, University "Federico II," Naples, Italy.
Godfrey D PearlsonOlin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut.
Derin CobiaDepartment of Psychology and Neuroscience Center, Brigham Young University, Provo, Utah.
Fabrizio PirasLaboratory of Neuropsychiatry, Scientific Institute for Research, Hospitalization and Healthcare, Santa Lucia Foundation, Rome, Italy.
Nerisa BanajLaboratory of Neuropsychiatry, Scientific Institute for Research, Hospitalization and Healthcare, Santa Lucia Foundation, Rome, Italy.
Daniela VecchioLaboratory of Neuropsychiatry, Scientific Institute for Research, Hospitalization and Healthcare, Santa Lucia Foundation, Rome, Italy.
Marjolein E A BarendseDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, the Netherlands.
Neeltje E M van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Center, Rotterdam, the Netherlands.
Hang Joon JoDepartment of Biomedical Engineering, Graduate School of Biomedical Sciences and Engineering, Hanyang University, Seoul, South Korea; Department of Physiology, College of Medicine, Hanyang University, Seoul, South Korea.
Kang SimWest Region, Institute of Mental Health, Singapore, Singapore.
Yann QuidéSchool of Psychology, University of New South Wales, Sydney, New South Wales, Australia; Neuroscience Research Australia, Randwick, New South Wales, Australia.
Melissa J GreenNeuroscience Research Australia, Randwick, New South Wales, Australia; School of Clinical Medicine, Discipline of Psychiatry and Mental Health, UNSW Sydney, Sydney, New South Wales, Australia.
Rachael SlateDepartment of Psychiatry, Department of Physical Medicine and Rehabilitation, University of Toledo, Toledo, Ohio.
Giacomo CecerePsychiatric Hospital, University of Zurich, Zurich, Switzerland.
Wolfgang OmlorPsychiatric Hospital, University of Zurich, Zurich, Switzerland.
Stephanie HomanPsychiatric Hospital, University of Zurich, Zurich, Switzerland.
Philipp HomanPsychiatric Hospital, University of Zurich, Zurich, Switzerland.
Sophia I ThomopoulosImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California.
Apulian Network on Risk for Psychosis
Jessica A TurnerDepartment of Psychiatry and Behavioral Health, Ohio State Wexner Medical Center, Columbus, Ohio.
Theo G M van ErpClinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, California; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, California.
Paul M ThompsonImaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of University of Southern California, Los Angeles, California.
Alessandro BertolinoDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy.
Giulio PergolaDepartment of Translational Biomedicine and Neuroscience-University of Bari Aldo Moro, Bari, Italy; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, Maryland; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: giulio.pergola@uniba.it.

Funding

Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
STRUCTURE, FUNCTION AND COGNITION IN SCHIZOPHRENIAP50MH071616 · NIMH · WASHINGTON UNIVERSITY · PI THOMPSON, PAUL A. · 2004 to 2008
$11.2M
NEURAL MECHANISMS OF SCHIZOPHRENIAP20RR021938 · NCRR · THE MIND RESEARCH NETWORK · PI HANLON, FAITH MARIE · 2008 to 2011
$9.4M
Mining the Genomewide Scan: Genetic Profiles of Structural Loss in Schizophrenia: AD/ADRD supplementR01MH094524 · NIMH · THE MIND RESEARCH NETWORK · PI CALHOUN, VINCE D, TURNER, JESS · 2012 to 2021
$6.3M
Neural Disconnection and Errant Visual Perception in Psychotic PsychopathologyU01MH108150 · NIMH · UNIVERSITY OF MINNESOTA · PI SPONHEIM, SCOTT R · 2016 to 2021
$5.0M
ENIGMA-COINSTAC-APOE2 Functional and structural connectome protective mechanisms for Alzheimer’s disease and mood disorders: Request for supplemental funds for NIH R01:1R01MH121246R01MH121246 · NIMH · OHIO STATE UNIVERSITY · PI CALHOUN, VINCE D, TURNER, JESS · 2019 to 2023
$5.0M
Gene Networks Influencing Psychotic Dysconnectivity in African AmericansR01MH106324 · NIMH · YALE UNIVERSITY · PI BLANGERO, JOHN, GLAHN, DAVID C · 2015 to 2019
$4.2M
3/5 Selective Antipsychotic Response to Clozapine in B-SNIP Biotype-1 (CLOZAPINE)R01MH124802 · NIMH · YALE UNIVERSITY · PI PEARLSON, GODFREY D · 2021 to 2025
$1.8M
3/5 Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services (BICEPS)R01MH127158 · NIMH · YALE UNIVERSITY · PI GODFREY D PEARLSON · 2022 to 2026
$1.5M
High-resolution Functional Imaging of Hippocampal Subfields in SchizophreniaR21MH097196 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAN ERP, THEODORUS G.M. · 2012 to 2013
$335k
CSRD VA I01 CX000227NCATS NIH HHS UL1 TR000153NCRR NIH HHS P20 RR021938NIMH NIH HHS P50 MH071616NIMH NIH HHS R01 MH094524NIMH NIH HHS R01 MH106324NIMH NIH HHS R01 MH121246NIMH NIH HHS R01 MH124802NIMH NIH HHS R01 MH127158NIMH NIH HHS R21 MH097196NIMH NIH HHS U01 MH108150
6 · The paper itself

Abstract

backgroundStructural brain differences in the thalamus and the cortex have been widely reported in schizophrenia (SCZ) relative to neurotypical control individuals (NCs). Most previous studies examined the thalamus as a whole as a single region of interest. In addition, findings in individuals at familial high risk for SCZ (FHRs) remain inconclusive. Here, we investigated whether local and network-wide thalamic-related structural alterations vary as a function of familial risk for SCZ.

methodsStructural magnetic resonance imaging scans were obtained from 5197 participants (NC, n = 3409; FHR, n = 257; SCZ, n = 1531) across 32 cross-sectional samples within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Random-effects meta-analyses and network analyses were conducted on 1) local thalamic alterations (volume estimates of 7 thalamic subdivisions) and 2) network-wide thalamic alterations (thickness and surface-related thalamocortical/corticocortical covariation patterns) across groups (NC, FHR, SCZ).

resultsIndividuals with SCZ showed significantly lower gray matter volume estimates in the anterior, pulvinar, medial, posterior, and ventral thalamic subdivisions compared with NCs (false discovery rate-corrected q [q

conclusionsResults revealed lower thalamic volume estimates in individuals with SCZ but not in FHRs, hence yielding no evidence of a familial risk trait, whereas thalamocortical and corticocortical covariation estimates were associated with familial risk for SCZ. These findings suggest that, once the thalamus is parsed into subdivisions, network-wide thalamocortical features may identify trait-dependent, neurobiological correlates of genetic risk for SCZ.

Indexed as

Cerebral CortexNerve NetSchizophreniaThalamusAdultCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysOrgan SizeYoung AdultFamilial high risk for schizophreniaMeta-analysesMorphometric measuresStructural neuroimagingThalamic subdivisionsThalamocortical networks

Identifiers

PMID40345610
PMCPMC13169515

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.