ReviewNeurobiology of learning and memory2025
Memory processing by hippocampal adult-born neurons.
Review in Neurobiology of learning and memory, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Tau knockout mitigates long-term cognitive impairment following neonatal sepsis via mechanisms involving dendritic structural remodelling and adult hippocampal neurogenesis.Journal of neuroinflammation · 2026Article
- Acute hyperexcitability differentially affects hippocampal neurogenesis features and spatial memory.Frontiers in cellular neuroscience · 2026Article
- NLRP3 Inflammasome in Stress-Related Neuropsychiatric Disorders: Mechanisms of Neuron-Microglia-Astrocyte Crosstalk, HPA Axis Dysregulation, and Therapeutic Perspective.Biomolecules · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
This review provides an integrative overview of the functional roles of adult neurogenesis in the hippocampal dentate gyrus (DG), focusing specifically on its impact on memory processes across the lifespan. A distinguishing feature of this review is its systematic approach, organizing the contributions of adult-born neurons (ABNs) chronologically through the stages of memory-from initial encoding, through sleep-dependent consolidation, retrieval, and finally forgetting. Although the existence and extent of adult neurogenesis in the human DG remain debated, accumulating evidence suggests that ABNs support cognitive functions throughout adulthood. This perspective gains particular importance when considering cognitive decline associated with aging and neurological disorders such as Alzheimer's disease, which are linked to substantial reductions in adult neurogenesis. We compare traditional models of DG function with emerging evidence highlighting both shared and unique contributions of ABNs. For example, the DG is well-established for its role in pattern separation, and as key mediators of this function, ABNs-due to their transiently heightened plasticity and excitability-appear critical for discriminating novel or similar experiences. On the other hand, recent findings underscore the distinct and essential role of ABNs in memory consolidation during REM sleep, suggesting specialized functions of ABNs that are absent in developmentally born granule cells in the DG. Clinically, the potential therapeutic importance of enhancing neurogenesis in memory-related disorders, including post-traumatic stress disorder (PTSD), is emphasized, highlighting promising treatments such as memantine. Lastly, we outline key unresolved questions, advocating for future research aimed at understanding ABN-specific mechanisms. Far from being a mere evolutionary vestige, hippocampal ABNs represent dynamic and essential elements of neural plasticity that are critical for memory formation, adaptation, and resilience across the lifespan.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.