Evidence map›Paper›PMID 40345266›Full record

ArticleAlcohol (Fayetteville, N.Y.)2025

An exploratory study of cytokine and inflammatory profiles between young adult low-risk and at-risk drinkers.

Mariann R Piano, Shane A Phillips, Chueh-Lung Hwang, Keng-Yu Chang, Kevin M Najarro, Rachel H McMahan, Elizabeth J Kovacs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariann R PianoSchool of Nursing, Vanderbilt University, Nashville, TN, USA. Electronic address: mariann.r.piano@vanderbilt.edu.
Shane A PhillipsDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, IL, USA.
Chueh-Lung HwangDepartment of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
Keng-Yu ChangDepartment of Kinesiology, University of Texas at Arlington, Arlington, TX, USA.
Kevin M NajarroDepartment of Surgery, Division of GI, Trauma, and Endocrine Surgery, Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Rachel H McMahanDepartment of Surgery, Division of GI, Trauma, and Endocrine Surgery, Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Elizabeth J KovacsDepartment of Surgery, Division of GI, Trauma, and Endocrine Surgery, Alcohol Research Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.

Funding

Alcohol and Burn Trauma: Multi-organ Inflammatory ResponsesR35GM131831 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI ELIZABETH J. KOVACS · 2019 to 2026
$3.5M
NIGMS NIH HHS R35 GM131831
6 · The paper itself

Abstract

backgroundThis exploratory study examined plasma levels of pro-inflammatory cytokines, chemokines and growth factors as well as intestinal fatty acid-binding protein (iFABP) and zonulin levels between young adult male and female low-risk and at-risk drinkers.

methodsA total of 33 low-risk (phosphatidylethanol levels <20 ng/ml; 19 female) and 44 at-risk drinkers (phosphatidylethanol levels ≥20 ng/ml; 30 female) were included in this study. Fasting blood samples were obtained in all participants. A multiplex assay was used to measure 48 chemokines and growth factors. An enzyme-linked immunoassay was used to measure plasma levels of human iFABP and zonulin.

resultsWe found that in young female, at-risk drinkers had a lower level of granulocyte-macrophage colony-stimulating factor (p = 0.04) and platelet-derived growth factor BB (P = 0.04) than low-risk drinkers, while in males, an elevated level of interferon-gamma was found in at-risk drinkers compared to low-risk drinkers (P = 0.04). Intestinal fatty acid-binding protein levels were significantly higher and zonulin levels were significantly lower in at-risk-risk drinkers compared to low-risk drinkers (P = 0.001 and P = 0.02, respectively).

conclusionsThese findings suggest that at-risk drinking in young adults is associated with alterations in specific cytokines and proteins involved in intestinal barrier function.

Indexed as

Alcohol DrinkingCytokinesFatty Acid-Binding ProteinsInflammationAdultCholera ToxinFemaleGlycerophospholipidsHaptoglobinsHumansMaleProtein PrecursorsRisk FactorsYoung AdultCholera ToxinCytokinesFABP2 protein, humanFatty Acid-Binding ProteinsGlycerophospholipidsHaptoglobinsphosphatidylethanolProtein PrecursorszonulinAt-risk drinkingBinge drinkingCytokinesInflammatory markersIntestinal fatty acid-binding proteinYoung adultsZonulin

Identifiers

PMID40345266
PMCPMC12911964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.