ReviewJournal of clinical psychopharmacology
The Potential Benefits of Chromium and Selenium Supplementation Across Psychiatric Disorders and Symptoms.
Review in Journal of clinical psychopharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effects of aJournal of psychopharmacology (Oxford, England) · 2025Trial
- Integrative Analysis of Trace Elements, Oxidative Stress, and Psychological Distress in Epilepsy: Biochemical Profiling and In Silico Docking Insights.Neurochemical research · 2026Article
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe conception of psychiatric disorders as systemic diseases implies an important role of nutrition in mental health. Essential trace elements are present in very small amounts in the body, yet they are essential for many physiological functions.
methodsLittle is known about the potential role of chromium and selenium supplementation in mental disorders and other populations. To contribute to filling this gap, this review is focused on the possible benefits of chromium and selenium, alone or in combination with pharmacological treatments, in the treatment of mental disorders or psychiatric symptoms.
resultsChromium and selenium show promising effects on psychiatric symptoms across mental disorders. Selenium may have benefits on anxious-depressive symptoms in healthy populations and groups at risk of nutritional deficits and psychiatric symptoms, for example, women in the post-partum. In addition, chromium was linked to improved insulin sensitivity and glucose metabolism, which can benefit not only metabolic health but also mood regulation, with specific benefits on atypical symptoms of depression, such as appetite/weight gain. Selenium plays a role in reducing oxidative stress and inflammation, which may suggest positive effects on psychopathology and other conditions linked to these mechanisms.
conclusionsBoth trace elements may affect positively mental health and cardio-metabolic-inflammatory conditions, which have a strong link with psychiatric disorders and their prognosis. Despite the evidence is not conclusive, chromium and selenium supplementation are interesting options to investigate in future research on the personalization of treatment in mental disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.