ArticleAnimal models and experimental medicine2025
Influence of the arterial elastic component on the response to balloon angioplasty in femoral arteries of a healthy porcine model.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Influence of the arterial elastic component on the response to balloon angioplasty in femoral arteries of a healthy porcine model.Animal models and experimental medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThe efficacy of balloon angioplasty for treating peripheral artery disease is influenced by various factors, some of them not yet totally understood. This study aimed to evaluate the role of elastin content in vascular responses 28 days post-angioplasty using uncoated and paclitaxel-coated balloons with the same platform in femoral arteries of a healthy porcine model.
methodsEight animals underwent balloon angioplasty on the external and internal branches of femoral arteries. Histopathologic evaluation was conducted at follow-up to assess the elastin content, vascular damage, morphological features, and neointimal formation.
resultsThe elastin content was significantly higher in the external than in the internal femoral artery (p = 0.0014). After balloon angioplasty, it was inversely correlated with vascular injury score (ρ = -0.4510, p = 0.0096), neointimal inflammation (ρ = -0.3352, p = 0.0607), transmural (ρ = -0.4474, p = 0.0103) and circumferential (ρ = -0.4591, p = 0.0082) smooth muscle cell loss, presence of proteoglycans (ρ = -0.5172, p = 0.0024), fibrin deposition (ρ = -0.3496, p = 0.0499), and adventitial fibrosis (ρ = -0.6229, p = 0.0002). Neointimal formation inhibition with paclitaxel was evident only in arteries with disruption of the internal elastic lamina, with a significant smaller neointimal area in arteries treated with paclitaxel-coated balloons compared to uncoated balloons (median [Q1-Q3]: 10.25 [7.49-15.64] vs. 24.44 [18.96-30.52], p = 0.0434).
conclusionsElastin content varies between branches of the femoral artery and significantly influences the integrity of the internal elastic lamina, the vessel's adaptive response, and paclitaxel efficacy after balloon angioplasty.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.