Evidence map›Paper›PMID 40345152›Full record

ArticleJournal of pediatric gastroenterology and nutrition2025

Effect of glycerin on colonic motility in children.

Julia M J van der Zande, Anna E Leone, Shruthi Srinivas, Richard J Wood, Marc A Benninga, Raul E Sanchez, Neetu Bali Puri, Karla Vaz, Desale Yacob, Carlo Di Lorenzo and 1 more

Abstract read
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In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Effect of glycerin on colonic motility in children.Journal of pediatric gastroenterology and nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia M J van der ZandeDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0009-0007-7500-7847
Anna E LeoneDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Shruthi SrinivasDepartment of Colorectal and Pelvic Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
Richard J WoodDepartment of Colorectal and Pelvic Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
Marc A BenningaDepartment of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Raul E SanchezDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Neetu Bali PuriDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Karla VazDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Desale YacobDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Carlo Di LorenzoDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Peter L LuDivision of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.

Funding

Cultuurfonds, with support from the Jadefonds; Amsterdam University FundNone
6 · The paper itself

Abstract

objectiveColonic manometry (CM) involves measurement of colonic neuromuscular activity and administration of a stimulant laxative, most commonly bisacodyl, which is part of the study protocol. Glycerin is another laxative used in the treatment of constipation. Our objective was to evaluate the effect of glycerin on colonic motility and compare the response to glycerin with each patient's response to bisacodyl.

methodsWe performed a retrospective review of all CM studies performed between May 2015 and May 2022. All studies with glycerin administration were included. Patient demographics, medical and surgical history, and results of each CM, including name, number, and dose of stimulant laxatives administered, colonic motor response after each stimulant, and final interpretation, were recorded.

resultsWe included 131 CM studies in 125 patients (53% female, median age at CM 10 years, interquartile range 7-14 years). Compared to bisacodyl, glycerin more commonly triggered fully propagated high-amplitude propagating contractions (HAPCs; 35% vs. 13%, p < 0.001) and led to a greater extent of propagation (propagation to sigmoid vs. to descending colon, p < 0.001). In 36% of studies, glycerin led to an improved response (stimulation of HAPCs when they were absent after bisacodyl, or HAPCs propagating through a greater extent of colon) compared to bisacodyl. In studies with an improved response, the median dose of glycerin in mL/kg was not significantly different compared to studies with the same/worse response.

conclusionGlycerin can trigger HAPCs in patients in whom bisacodyl was not able to do so. Incorporation of glycerin into standard CM protocols should be considered.

Indexed as

ColonConstipationGastrointestinal MotilityGlycerolLaxativesAdolescentBisacodylChildFemaleHumansMaleManometryRetrospective StudiesBisacodylGlycerolLaxativesbisacodylcolonic manometryhigh‐amplitude propagating contractionspediatrics

Identifiers

PMID40345152
PMCPMC12210795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.