Evidence map›Paper›PMID 40344623›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Ultrasound-Triggered Nanocomposite "Lever" Hydrogels with a Full Repair System Accelerates Diabetic Foot Ulcer Repair.

Yuting Shen, Shaoyue Li, Xiaodong Hou, Jifeng Yu, Yuli Zhu, Chongke Zhao, Zhiyuan Niu, Xin Guan, Bing Xiong, Sirui Wang and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. ROS-Balancing MXene/MoSeSmall (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  5. Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Recent Advances in Nanozymes Toward Diabetic Foot Ulcers.International journal of nanomedicine · 2026
    Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yuting ShenDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Shaoyue LiDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Education and Research Institute, School of Medicine, Tongji University, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, 200072, China.
Xiaodong HouDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Education and Research Institute, School of Medicine, Tongji University, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, 200072, China.
Jifeng YuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yuli ZhuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chongke ZhaoDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Zhiyuan NiuDepartment of Medical Ultrasound, Henan Provincial People's Hospital, School of Medicine, Henan University, Zhengzhou, Henan Province, 450003, China.
Xin GuanDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Bing XiongDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Sirui WangDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yifei YangDepartment of Medical Ultrasound Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, 226001, China.
Xiao LiDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Liping SunDepartment of Medical Ultrasound, Center of Minimally Invasive Treatment for Tumor, Shanghai Tenth People's Hospital, Ultrasound Education and Research Institute, School of Medicine, Tongji University, Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment, Shanghai, 200072, China.
Shengbo WuUltrasound Department, Zhejiang Hospital, No. 1229 Gudun Road, Xihu District, Hangzhou, Zhejiang Province, 310013, China.
Bin HuangUltrasound Department, Zhejiang Hospital, No. 1229 Gudun Road, Xihu District, Hangzhou, Zhejiang Province, 310013, China.
Huixiong XuDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0000-0002-8699-854X
Haohao YinDepartment of Ultrasound, Institute of Ultrasound in Medicine and Engineering, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.ORCID https://orcid.org/0000-0002-5404-7336

Funding

National Natural Science Foundation of China 81927801National Natural Science Foundation of China 82151318National Natural Science Foundation of China 82202174Scientific Research and Development Fund of Zhongshan Hospital of Fudan University GrantZSZP202419
6 · The paper itself

Abstract

Diabetic foot ulcers (DFUs) are a complex mixture of neuropathy, peripheral arterial disease, and infection, where excessive reactive oxygen species (ROS) exacerbates inflammation and impairs healing. Therefore, there is an urgent need to design a hydrogel dressing with a 'lever' function to balance ROS levels in the wound to achieve both antimicrobial and anti-inflammatory effects on DFUs. In this study, we synthesised ROS-responsive diselenide liposomes loaded with a pro-skin healing factor (ergothioneine (ET)), thrombin, and a sonosensitizer (HMME) and constructed nanocomposite 'lever' hydrogels modulated by ultrasound (US). During early infection, sonodynamic therapy (SDT) under US generates bactericidal ROS, cleaving diselenide bonds to release ET and thrombin. Upon US cessation, thrombin/fibrinogen forms an in situ gel, while ET scavenges residual ROS and promotes M2 macrophage polarization in later stages. In addition, the potential immunomodulatory mechanisms of the nanocomposite 'lever' hydrogels were investigated via RNA sequencing. In conclusion, the novel nanocomposite 'lever' hydrogels effectively achieved a balance between ROS production and annihilation during different stages of wound repair while providing antibacterial and anti-inflammatory properties to promote neovascularisation and improve diabetic peripheral neuropathy. In conclusion, by precisely controlling ROS levels across wound-healing phases, this strategy offers a promising solution for refractory DFUs.

Indexed as

Diabetic FootHydrogelsNanocompositesUltrasonic TherapyWound HealingAnimalsHumansMaleMiceReactive Oxygen SpeciesHydrogelsReactive Oxygen Speciesanti‐inflammatory and antibacterialdiabetic foot ulcersergothioneinenanocomposite “lever” hydrogelsreactive oxygen species regulation

Identifiers

PMID40344623
PMCPMC12199430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.