ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Real-time sensing-integrated organoid-on-a-chip platforms: Technological progress and emerging biomedical applications.Bioactive materials · 2026Review
- [Research advances on the application of skin appendage organoids in wound repair].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Review
- Research Progress on Construction Technology of 3D Human Skin Models and Its Application Prospects in Dermatology.International journal of molecular sciences · 2026Review
- Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026Review
- Combining advanced 3D spheroid-based skin models with deep-learning-based image analysis enables in-depth investigation of keratinocyte differentiation and barrier function.Frontiers in bioengineering and biotechnology · 2026Article
- Beyond monolayers: a comparative analysis of 2D cell cultures and 3DFrontiers in bioengineering and biotechnology · 2026Review
- Multiscale Construction, Evaluation, and Application of Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
It has been a challenge to develop skin models which exhibit the key characteristics of the human skin and facilitate high-throughput drug screening. In this study, a method is developed to construct microspheric skin organoids based on spinning bioreactors. The organoid consists of a core-shell structure to mimic the bilayered skin structure, where the shell is composed of cultured human keratinocytes, resembling the epidermis, and the core, which mimics the dermis, comprises human dermal fibroblasts and collagen. In fabrication of the organoid, the cores are cultured with keratinocytes in spinner flasks under defined conditions to facilitate epidermal growth and differentiation to form mature barrier. To enable efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt activation, and Minoxidil is identified to induce epidermal Wnt/beta-catenin pathway signaling. Thus, the study has developed a novel method for efficient preparation of uniform microspheric skin organoids with potential applications for high-throughput drug testing and screening.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.