Evidence map›Paper›PMID 40344587›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Efficient and Rapid Arylation of NH₂-Unprotected Bromobisindole Ethanamines via Suzuki-Miyaura Coupling: Generating New Leads Against Leishmania.

Alessandro Buono, Aurora Diotallevi, Sara Maestrini, Michele Verboni, Paula Kiuru, Luca Galluzzi, Andrea Duranti, Diego Olivieri, Simone Lucarini

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandro BuonoDepartment of Biomolecular Sciences, Section of Chemistry and Pharmaceutical Technologies, University of Urbino Carlo Bo, Campus Scientifico E. Mattei, via Ca' le suore 2, Urbino, 61029, Italy.
Aurora DiotalleviDepartment of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino Carlo Bo, Via Arco d'Augusto 2, Fano, 61032, Italy.
Sara MaestriniDepartment of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino Carlo Bo, Via Arco d'Augusto 2, Fano, 61032, Italy.
Michele VerboniDepartment of Biomolecular Sciences, Section of Chemistry and Pharmaceutical Technologies, University of Urbino Carlo Bo, Campus Scientifico E. Mattei, via Ca' le suore 2, Urbino, 61029, Italy.
Paula KiuruDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O. Box 56, Helsinki, 00014, Finland.
Luca GalluzziDepartment of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University of Urbino Carlo Bo, Via Arco d'Augusto 2, Fano, 61032, Italy.
Andrea DurantiDepartment of Biomolecular Sciences, Section of Chemistry and Pharmaceutical Technologies, University of Urbino Carlo Bo, Campus Scientifico E. Mattei, via Ca' le suore 2, Urbino, 61029, Italy.
Diego OlivieriDepartment of Biomolecular Sciences, Section of Chemistry and Pharmaceutical Technologies, University of Urbino Carlo Bo, Campus Scientifico E. Mattei, via Ca' le suore 2, Urbino, 61029, Italy.
Simone LucariniDepartment of Biomolecular Sciences, Section of Chemistry and Pharmaceutical Technologies, University of Urbino Carlo Bo, Campus Scientifico E. Mattei, via Ca' le suore 2, Urbino, 61029, Italy.ORCID https://orcid.org/0000-0002-3667-1207

Funding

European Union-NextGenerationEU within the framework of PNRRItalian Ministry of University and ResearchNational Innovation Ecosystem ECS00000041National Innovation Ecosystem H33C22000430006National Innovation Ecosystem J13C22000430001
6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease which presents significant global health challenges due to the lack of effective vaccines and the limitations of existing chemotherapeutics in view of their toxicity, resistance, and high costs. In this study, we realized a library of novel bisindole derivatives as potential antileishmanial agents through a rapid Suzuki-Miyaura coupling reaction, utilizing NH

Indexed as

AminesAntiprotozoal AgentsIndolesLeishmania infantumBoronic AcidsLeishmaniasisPhosphorylcholineStructure-Activity RelationshipAminesAntiprotozoal AgentsBoronic AcidsIndolesmiltefosinePhosphorylcholinebisindoleslate‐stage derivatizationLeishmaniapalladiumSuzuki‐Miyaura coupling

Identifiers

PMID40344587
PMCPMC12319374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.