SynthesisJournal of cellular and molecular medicine2025
Relationship Between MCP-1 Levels in GCF and Periodontitis: A Systematic Review With Meta-Analysis and Analysis of Molecular Interactions.
Synthesis in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Artificial Intelligence Anxiety Levels Among Healthcare Professionals: A Systematic Review and Meta-Analysis.Journal of nursing management · 2026Pooled it
- Effect of type 1 diabetes on the inflammatory response in periodontal disease.Frontiers in immunology · 2025Observational
- From routine periodontal therapy to Alzheimer's disease early detection: A scoping review.Journal of Alzheimer's disease reportsReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocyte chemoattractant protein 1 (MCP-1) is involved in monocyte chemotaxis, endothelial activation and regulation of leukocyte function in biological activities that promote inflammation, such as in periodontitis. A systematic review and meta-analysis was conducted with the primary objective of investigating the roles of MCP-1 in the gingival crevicular fluid (GCF) of subjects with chronic periodontitis compared to periodontally healthy subjects. The study protocol adhered to PRISMA guidelines. Digital searches were carried out across several databases, including PubMed, Dentistry & Oral Science Source, ScienceDirect, Scopus, Web of Science and Google Scholar. The quality of the studies was evaluated using the JBI tool for cross-sectional studies and clinical trials. To assess the concentration of MCP-1 in the GCF of the exposure group versus the control group, a meta-analysis was conducted employing a random-effects model. The search strategy yielded 1694 articles, with 14 studies meeting the inclusion criteria and 10 articles subjected to quantitative analysis. A total of 497 subjects were examined, comprising 298 cases and 199 controls. The meta-analysis indicated a significant increase in MCP-1 levels in the GCF of individuals with chronic periodontitis compared to healthy subjects (GCF: SMD = 20.29, 95% CI: 10.33-30.25, Z = 3.992, p = 0.001*). GCF MCP-1 levels are elevated in periodontitis compared to healthy controls, suggesting its potential future use as a diagnostic tool in clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.