Evidence map›Paper›PMID 40344397›Full record

ArticlePediatric pulmonology2025

Continuous Application of Closed-Loop FiO2-Control in Extremely Preterm Infants: A Matched Cohort Single-Center Study.

Koen P Dijkman, Jesse J Delbressine, Jeanne P Dieleman, Thilo Mohns, Peter Andriessen, Carola van Pul, Irwin K M Reiss, Axel R Franz, Hendrik J Niemarkt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Koen P DijkmanDepartment of Neonatology, Máxima MC, Veldhoven, The Netherlands.ORCID https://orcid.org/0000-0003-0765-929X
Jesse J DelbressineDepartment of Applied Physics, TU/e Eindhoven, University of Technology, Eindhoven, The Netherlands.
Jeanne P DielemanMMC Science Office, Máxima MC, Veldhoven, The Netherlands.
Thilo MohnsDepartment of Neonatology, Máxima MC, Veldhoven, The Netherlands.
Peter AndriessenDepartment of Neonatology, Máxima MC, Veldhoven, The Netherlands.
Carola van PulDepartment of Applied Physics, TU/e Eindhoven, University of Technology, Eindhoven, The Netherlands.
Irwin K M ReissDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC, Rotterdam, The Netherlands.
Axel R FranzDepartment of Neonatology and Centre for Paediatric Clinical Studies, University Children's Hospital Tübingen, Tübingen, Baden-Württemberg, Germany.
Hendrik J NiemarktDepartment of Neonatology, Máxima MC, Veldhoven, The Netherlands.ORCID https://orcid.org/0000-0002-0844-7208

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

introductionAutomated or closed-loop FiO2-control (FiO2-c) has been developed to maintain oxygen saturation (SpO2) within a target range more effectively. However, knowledge of the effects of prolonged use of FiO2-c in extremely preterm infants during a more integral part of NICU admission is limited.

methodsTwenty five extremely preterm infants (gestational age [GA] < 28 weeks) who survived until NICU discharge and received FiO2-c by Predictive Intelligent Control of Oxygenation (PRICO) were matched 1:1 for GA, birthweight, sex and survival to a cohort receiving routine manual FiO2-c. The proportions of time within the SpO2 target range, (severe) hypoxia, hyperoxia, FiO2 and SpO2 for all days and days on supplemental oxygen, for both the whole period and per week, were compared.

resultsInfants in the FiO2-c cohort received the intervention during 98% of the 7-week study period. Overall, with FiO2-c, a small, non-significant increase in time within SpO2 target range was observed: mean difference 0.5% (95% CI [-5.0, 6.0]). However, when requiring supplemental oxygen during the first 2 weeks of life, time within SpO2 target range significantly increased with FiO2-c, while time in hyperoxia decreased: mean differences in Week 1: 9.9% (95% CI [3.1, 16.7]) and -10.2% (95% CI [-17.1, -3.3]); in Week 2: 9.5% (95% CI [1.4, 17.6]) and -9.9% (95% CI [-19.2, -0.2]).

conclusionDespite limited overall effect, continuous use of FiO2-c in extremely preterm infants requiring supplemental oxygen was associated with an increased time within the SpO2 target range during the first 2 weeks of life, a critical window for hyperoxia-related diseases.

Indexed as

Infant, Extremely PrematureOxygenOxygen Inhalation TherapyOxygen SaturationCohort StudiesFemaleGestational AgeHumansHyperoxiaHypoxiaInfant, NewbornIntensive Care Units, NeonatalMaleOximetryOxygenautomated oxygen controlclosed loop oxygen controlhyperoxiahypoxiapreterm

Identifiers

PMID40344397
PMCPMC12063471

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.