Evidence map›Paper›PMID 40344368›Full record

ArticleOrthopaedic surgery2025

Comparative Perioperative Inflammatory and Functional Outcomes in Single Versus Multiple Joint Replacements for Hemophilic Arthritis: A Pilot Study.

Maoye Shen, Ping Qian, Wenxue Jiang, Shanyou Yuan, Gaorui Cai, Zhenzhong Zhou, Xiaona Wu, Jinghua Wang, Xianjia Ning, Lixia Song

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Maoye ShenDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Ping QianDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Wenxue JiangDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Shanyou YuanDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Gaorui CaiDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID https://orcid.org/0000-0002-2953-9523
Zhenzhong ZhouDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Xiaona WuDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jinghua WangCenter of Clinical Epidemiology, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Xianjia NingCenter of Clinical Epidemiology, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.
Lixia SongDepartment of Orthopedics, Shenzhen Third People's Hospital and the Second Hospital Affiliated With the Southern University of Science and Technology, Shenzhen, Guangdong, China.ORCID https://orcid.org/0009-0002-2101-253X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHemophilic arthritis is a progressive joint disease often requiring surgical intervention in advanced stages. However, comparative evidence on perioperative inflammatory and coagulation responses between single joint replacement (SJR) and multiple joint replacement (MJR) remains scarce. This study aimed to assess the differences in perioperative outcomes, including inflammatory responses, blood transfusion requirements, and functional recovery, to guide surgical decision-making for hemophilic arthritis patients.

methodsThis retrospective study included 29 male patients with moderate-to-severe hemophilic arthritis who underwent SJR (n = 12) or MJR (n = 17) at a single institution from October 2020 to October 2023. Data on inflammatory markers (CRP, ESR, IL-6, WBC), hemoglobin levels, blood transfusion requirements, and joint mobility were collected for the immediate postoperative period (days 1-14). Trends in inflammatory markers were analyzed using average percent changes (APC), and differences in outcomes were evaluated using the Mann-Whitney U test for continuous variables and Fisher's exact test for categorical variables. Longitudinal changes were analyzed using mixed-model repeated measures ANOVA with time points as fixed effects and subjects as random effects. Statistical significance was set at p < 0.05.

resultsPostoperative CRP levels declined significantly in both groups, with APCs of -9.06% (95% CI: -15.63 to -1.98, p < 0.05) for the SJR group and -8.42% (95% CI: -16.18 to 0.06) for the MJR group. ESR showed a significant upward trend, with APCs of 10.82% (95% CI: 0.95-21.65, p < 0.05) in the SJR group and 17.54% (95% CI: 11.71-23.67, p < 0.05) in the MJR group. Blood transfusion requirements were comparable, with median transfusion volumes of 0.00 units (IQR: 3.50) for SJR and 0.00 units (IQR: 3.75) for MJR (p = 0.761). Notably, joint mobility scores were significantly better in the MJR group (mean: 31.88, SD: 19.31) compared to the SJR group (mean: 18.33, SD: 10.39; p = 0.030). Despite the larger surgical scope of MJR, no significant differences in infection or bleeding risks (SJR:median transfusion = 0.00 units, IQR: 3.50; MJR:median transfusion, 0.00 units, IQR: 3.75. p = 0.761) were observed between the groups.

conclusionThis study demonstrates that MJR offers superior functional recovery compared to SJR, without increasing the risks of infection, bleeding, or transfusion. These findings support MJR as a safe and effective surgical option for hemophilic arthritis patients when appropriate perioperative management protocols are implemented. Future studies with larger sample sizes and long-term follow-up are needed to validate these results and explore extended outcomes.

Indexed as

ArthritisArthroplasty, ReplacementHemophilia AAdultBlood TransfusionHumansInflammationMaleMiddle AgedPilot ProjectsRecovery of FunctionRetrospective StudiesTreatment Outcomeblood transfusionhemophilic arthritisjoint replacementperioperative inflammationsurgical outcomes

Identifiers

PMID40344368
PMCPMC12146121

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