ArticleDiabetes, obesity & metabolism2025
Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Tumour-proximal deep serum proteomics identifies biomarkers associated with ovarian cancer.Molecular oncology · 2026Article
- Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.Aging cell · 2026Article
- Age-Related Changes in Predictors of BMI in 6, 9 and 12-Year-Old Boys and Girls: The NW-CHILD Study.Journal of functional morphology and kinesiology · 2025Article
- Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.Diabetes, obesity & metabolism · 2025Article
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Abstract
introductionWhile some studies have explored associations between weight change and blood proteins, most have been intervention-based, offering limited insight into proteomic associations with long-term weight gain. It remains unclear whether plasma proteins are related to BMI fluctuation over time. This study investigates associations of long-term BMI changes and fluctuations with over 1000 plasma proteins involved in cardiometabolic and inflammation functions. DATA AND
methodsThe study included 304 Finnish adult twins (117 men) born before 1958 from the Older Finnish Twin Cohort, with BMI data spanning five time points (1975, 1981, 1990, 2011 and 2012-2014). Proteomic data were derived from blood samples collected at the last BMI measurement. Linear mixed-effects models analysed individual BMI trajectories, producing intercepts (baseline BMI) and slopes (BMI change rates). BMI fluctuation was calculated as the average squared deviation from expected BMI across time points. Associations between BMI changes/fluctuation and (i) 1231 plasma proteins related to cardiometabolic and inflammatory functions and (ii) polygenic risk scores for BMI (PRS
resultsA total of 135 proteins were associated with changes in BMI over 40 years, while 17 proteins were linked to fluctuation in BMI: 12 associations (10 with BMI changes and 2 with fluctuation) remained significant in within-twin pair analyses. PRS
conclusionThis study highlights significant associations between plasma proteins and long-term BMI changes and fluctuations, with no evidence of PRS
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