Evidence map›Paper›PMID 40344254›Full record

ArticleWorld journal of surgery2025

The Impact of KRAS Status on Long-Term Outcomes After Thermal Ablation and Hepatic Resection for Liver-Only Colorectal Metastases: A New Clue for Tailoring Surgical Strategy on Tumor Biology?

Fabio Giannone, Federico Sangiuolo, Gianluca Cassese, Marco Palucci, Celeste Del Basso, Alfonso Lapergola, Giorgio Badessi, Reza Kianmanesh, Patrick Pessaux, Rami Rhaiem and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Fabio GiannoneRobotic, Oncologic and HPB Surgery, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Federico SangiuoloRobotic, Oncologic and HPB Surgery, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Gianluca CasseseRobotic, Oncologic and HPB Surgery, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Marco PalucciRobotic, Oncologic and HPB Surgery, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Celeste Del BassoRobotic, Oncologic and HPB Surgery, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Alfonso LapergolaDepartment of Visceral and Digestive Surgery, University Hospital of Strasbourg, Strasbourg, France.
Giorgio BadessiDepartment of HBP and Digestive Oncological Surgery, Robert Debré University Hospital, University Reims Champagne-Ardenne, Reims, France.
Reza KianmaneshDepartment of HBP and Digestive Oncological Surgery, Robert Debré University Hospital, University Reims Champagne-Ardenne, Reims, France.
Patrick PessauxDepartment of Visceral and Digestive Surgery, University Hospital of Strasbourg, Strasbourg, France.
Rami RhaiemDepartment of HBP and Digestive Oncological Surgery, Robert Debré University Hospital, University Reims Champagne-Ardenne, Reims, France.
Fabrizio PanaroRobotic, Oncologic and HPB Surgery, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKRAS mutation is a negative prognostic factor for colorectal liver metastases (CRLM). Thermal ablation (TA) is considered a valid alternative to liver resection (LR) for CRLM in selected cases. This study aims to investigate the influence of KRAS status on long-term outcomes of TA during LR. MATERIALS AND

methodsThis is a retrospective analysis of patients undergoing surgery for CRLM in two hepatobiliary centers. Patients were divided into two groups: LR or LR + TA, and long-term results were investigated according to KRAS status.

results220 patients were included, of whom 74 (33.6%) were KRAS mutated. TA was performed in association with LR in 42 mutated (mKRAS) tumors (56.7%). Multivariate analysis in mKRAS patients showed that synchronous disease (p = 0.014), performing TA (p = 0.044), performing two or more TA (p = 0.032), and N2 status (p < 0.001) were independently associated with DFS. TA was more frequently associated with a liver-only recurrence, both in mutated and wt tumors, but with a higher risk in mKRAS (p = 0.013 vs. p = 0.048).

conclusionCRLM surgical treatment should be tailored to KRAS status because TA may potentially be less effective in mutated patients during surgical resection. This is even more important in the case of multiple ablations.

Indexed as

Colorectal NeoplasmsHepatectomyLiver NeoplasmsProto-Oncogene Proteins p21(ras)AdultAgedFemaleHumansMaleMiddle AgedMutationRetrospective StudiesTreatment OutcomeKRAS protein, humanProto-Oncogene Proteins p21(ras)colorectal liver metastasesliver resectionoutcomesthermal ablation

Identifiers

PMID40344254
PMCPMC12134197

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.