ArticleThe Laryngoscope2025
Hyams Grade and Ki-67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma.
Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Hyams Grade and Ki-67 as Predictive Factors for Primary Treatment Failure in Olfactory Neuroblastoma.The Laryngoscope · 2025Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveTumor progression and first recurrence (TPR) after curative treatment for olfactory neuroblastoma can be regarded as primary treatment failure. Prognostic parameters for TPR and primary tumor-progression-free and recurrence-free survival (TPRFS) have not been sufficiently investigated in the literature.
methodsData for 43 patients were analyzed retrospectively to evaluate prognostic parameters for TPR after curative treatment for olfactory neuroblastoma: age, age < / ≥ 50 years, sex, tumor classifications, curative therapy (monotherapy vs. combined, R0 vs. R1/2/x resection), Hyams-grade (grades, grade I-II/III-IV), and Ki-67 labeling index (values, labeling index < / ≥ 10%). The primary endpoints were TPR and TPRFS. Parameters that were significant after univariate analysis and Kaplan-Meier survival analysis were included in multiple regression and Cox regression analysis.
resultsAfter univariate analysis, younger age (p = 0.032) and higher Ki-67 values (p = 0.001) were significantly negatively associated with time to the development of TPR. TPRFS according to Kaplan-Meier was significantly poorer with Hyams-grade III-IV (p = 0.002) and Ki-67 ≥ 10% (p = 0.001). After Cox regression analysis, TPRFS according to Kaplan-Meier was weekly significantly poorer for younger age (p = 0.033) and highly significantly worse for Hyams-grade III-IV (p = 0.005) and a Ki-67 LI ≥ 10% (p = 0.009). Tumor-stage classifications and all therapeutical parameters were not significantly associated with TPRFS.
conclusionsOut of a panel of parameters tested, younger age, Hyams-grade III-IV, and a Ki-67 LI ≥ 10% were significantly associated with a significantly worse TPRFS after multivariate Cox regression analysis. In particular, parameters such as Hyams-grade and the Ki-67 LI should be included in management considerations in olfactory neuroblastoma at an early stage. LEVEL OF EVIDENCE: 3:
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