ArticleJournal of the American Chemical Society2025
Self-Regulating Hydrogel with Reversible Optical Activity in Its Gel-to-Gel Transformation.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
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Who cites it
13 citing papers in PubMed.
- Adaptive Hyaluronic Acid Hydrogels for Regenerative Wound Healing: From Microenvironment Sensing to ECM Reprogramming and Precise Tissue Regeneration.Macromolecular rapid communications · 2026Review
- Stable Protein-Based G-Quadruplex-Derived Supramolecular Bioinks as Tunable ECM-Mimetic Constructs Assembled by Combining Non-Covalent and Covalent Strategies.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- G-quartet driven adaptive hydrogels that integrate constitutional dynamics for antibacterial action and tissue repair.iScience · 2026Article
- Fluorescent Supramolecular Gels Based on D-Sorbitol Derivatives.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Click/release reaction and SONature communications · 2026Article
- Quantitative Assessment of Hydrogel Printability in Extrusion Bioprinting.Gels (Basel, Switzerland) · 2026Review
- Chiral inheritance effect in the reactive cystine-based coassembly system.Nature communications · 2026Article
- Peptide Sequence Programmed Piezoelectric Response by Supramolecular Self-Assembly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Guanine nucleotide directed co-assembly with Pt-complexes for tailoring chiroptical properties and multimodal molecular recognition.Chemical science · 2026Article
- CuChemistry, an Asian journal · 2026Article
- A hydroxyl group dictates handedness, pitch, and mechanics in a crystalline covalent helical polymer.Science advances · 2025Article
- Dynamic Reconfiguration of Pt(II) Supramolecular Assemblies via Ligand Exchange.ACS applied materials & interfaces · 2025Article
- Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix's Complexity.ACS nano · 2025Review
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study reports a supramolecular gel system capable of dynamic gel-to-gel transformations and reversible inversion of optical activity between superhelical and single-helical structures without passing through a sol phase. Inspired by collagen-like adaptability, the system utilizes 4-pyridinylboronic acid and guanosine as building blocks. Hierarchical assembly is achieved through pH-responsive boronic ester formation and guanosine-mediated G-quadruplex stacking, enabling transitions between superhelices and single helices with opposite optical activity. The system employs three regulatory pathways: bidirectional pH modulation, monotonic pH increase, and monotonic pH decrease, demonstrating programmable and reversible control over chirality, morphology, and mechanical properties. In the autonomous pH regulation, we have created an out-of-equilibrium hydrogel system with controlled switching of optical activity. Unlike traditional gel-sol-gel systems, this gel maintains macroscopic stability during transformations. Our remarkable finding bridges the gap between static supramolecular assemblies and dynamic soft materials, offering a platform for designing functional, biomimetic systems. The combination of hierarchical organization, dynamic chirality control, and robust programmability positions this gel for applications in adaptive optics, responsive biomaterials, and programmable soft matter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.