ReviewACS biomaterials science & engineering2025
Silk Fibroin Methacrylation: Chemical Synthesis to Biomechanical Optimization in Tissue Engineering.
Review in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Composite Hydrogel Using Methacrylated Silk Fibroin and Mercaptolated Hyaluronic Acid with Encapsulating Zinc-Quercetin Nanozyme.Gels (Basel, Switzerland) · 2026Article
- Silk-Fibroin-Based Adhesive Hydrogels: Mechanistic Insights and Biomedical ApplicationsA Review.ACS omega · 2026Review
- Silk Fibroin-Derived Smart Living Hydrogels for Regenerative Medicine and Organoid Engineering: Bioactive, Adaptive, and Clinically Translatable Platforms.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, a major focus in the field of tissue engineering has been the search for a suitable biomaterial for clinical applications. Researchers have sought to optimize natural, synthetic, and hybrid options, with an aim to enhance biological, chemical, physical, and mechanical properties. In the past decade, silk fibroin has emerged as a promising approach due to its suitable properties. Specifically, the chemical modification of silk fibroin with methacrylate agents, namely glycidyl methacrylate, methacrylic anhydride, and gelatin methacryloyl, confers the material with improved biophysical properties. This review presents an in-depth overview of silk fibroin's structure and suitable properties, silk fibroin methacrylate synthesis and characterization techniques, and applications of silk fibroin in bone and cartilage, skin, and nerve tissue engineering. Challenges include a limited understanding of methacrylate agents on specific cell types, which can be addressed by further
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.