ArticlePloS one2025
Integrating genomics and transcriptomics reveals candidate genes affecting loin muscle area in Huaxi cattle.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Estimation of Genetic Parameters for Body Weight and Its Stability in Huaxi Cows from Xinjiang Region.Animals : an open access journal from MDPI · 2025Article
- New Sights into Bioinformatics of Gene Regulations and Structure.International journal of molecular sciences · 2025Article
- Correction: Integrating genomics and transcriptomics reveals candidate genes affecting loin muscle area in Huaxi cattle.PloS one · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Loin muscle area (LMA) is an indicator of carcass composition and is related to weight gain, animal musculature and meat quality traits. Therefore, integrating multi-omics data to reveal candidate genes affecting LMA has attracted extensive attention. We used the combined analysis method of GWAS and RNA-seq to find the candidate genes that affect the size of LMA. The association of 770K SNPs with the LMA captured four significant SNPs within or near three genes. Additionally, seven overlapping genes regarding LMA were determined via the analysis of differentially expressed genes (DEGs) and weighted gene co-expression network analysis (WGCNA). There is an overlapping gene (CD93) between the results of GWAS and DEGs. Through functional enrichment analysis of the above genes, candidate genes were identified as THBD, CD93, RIMS2, PLP1, SNCA, and NDUFS8, and it was found that they mainly affected the size of LMA by affecting muscle fiber diameter, muscle cell development, differentiation, and function. The findings provide valuable molecular insights into the mechanisms that influence LMA content in beef cattle.
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