Evidence map›Paper›PMID 40344068›Full record

ArticleScience advances2025

Continuous operation of battery-free implants enables advanced fracture recovery monitoring.

Kevin Albert Kasper, Gerardo Figueroa Romero, Dania L Perez, Avery M Miller, David A Gonzales, Jesus Siqueiros, David S Margolis, Philipp Gutruf

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kevin Albert KasperDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.ORCID 0009-0000-1242-831X
Gerardo Figueroa RomeroDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.ORCID 0009-0001-2513-5046
Dania L PerezDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.
Avery M MillerDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.ORCID 0009-0006-0297-306X
David A GonzalesDepartment of Orthopaedic Surgery, University of Arizona, Tucson, AZ 85721, USA.ORCID 0009-0003-0120-5761
Jesus SiqueirosDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.ORCID 0009-0008-6123-3592
David S MargolisDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-2936-7506
Philipp GutrufDepartment of Biomedical Engineering, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-7183-7268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Substantial hurdles in achieving a digitally connected body with seamless, chronic, high-fidelity organ interfaces include challenges of sourcing energy and ensuring reliable connectivity. Operation is currently limited by batteries that occupy large volumes. Wireless, battery-free operation is therefore paramount, requiring a system-level solution that enables seamless connection of wearable and implantable devices. Here, we present a technological framework that enables wireless, battery-free implant operation in freely moving subjects, with streaming of high-fidelity information from low-displacement, battery-free implants with little user interaction. This is accomplished using at-distance wirelessly recharged, wearable biosymbiotic devices for powering and communication with fully implantable NFC-enabled implants. We demonstrate this capability with osseosurface electronics that stream bone health insight. Eleven-month-long large animal studies highlight the ability of implants to relay information on bone health without negative impact on the subjects. Clinical translatability is shown through fracture healing studies that demonstrate biomarkers of bone union.

Indexed as

Fracture HealingFractures, BoneProstheses and ImplantsAnimalsElectric Power SuppliesHumansMonitoring, PhysiologicWearable Electronic DevicesWireless Technology

Identifiers

PMID40344068
PMCPMC12063648

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.