Evidence map›Paper›PMID 40344054›Full record

ArticleScience advances2025

Mac-1 regulates disease stage-specific immunosuppression via the nitric oxide pathway in autoimmune disease.

Wei Wang, Chunzhang Cao, Vishnuprabu Durairaj Pandian, Haofeng Ye, Hongxia Chen, Li Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wei WangDepartment of Physiology, Center for Vascular and Inflammatory Diseases, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.ORCID 0000-0002-0799-8171
Chunzhang CaoDepartment of Physiology, Center for Vascular and Inflammatory Diseases, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.ORCID 0009-0000-7973-6800
Vishnuprabu Durairaj PandianDepartment of Physiology, Center for Vascular and Inflammatory Diseases, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.ORCID 0000-0003-0142-9565
Haofeng YeJohns Hopkins Advanced Academic Programs, Johns Hopkins University of Arts and Sciences, Baltimore, MD, USA.
Hongxia ChenDepartment of Physiology, Center for Vascular and Inflammatory Diseases, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.ORCID 0000-0002-2159-3381
Li ZhangDepartment of Physiology, Center for Vascular and Inflammatory Diseases, School of Medicine, University of Maryland, Baltimore, Baltimore, MD, USA.ORCID 0000-0003-4659-4724

Funding

Targeting the Proinflammatory Activity of Integrin Mac-1 for Treatment of AtherosclerosisR01HL142909 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHANG, LI · 2019 to 2022
$2.3M
Ligand-dependent and cell type-specific functions of integrin CD11b/CD18 in multiple sclerosisR01NS110630 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI ZHANG, LI · 2019 to 2023
$1.7M
NHLBI NIH HHS R01 HL142909NINDS NIH HHS R01 NS110630
6 · The paper itself

Abstract

Integrin Mac-1 plays a critical role in the development of multiple sclerosis (MS); however, the underlying mechanism is not fully understood. Here, we developed a myeloid-specific Mac-1-deficient mouse. Using an experimental autoimmune encephalomyelitis (EAE) mouse model of MS, we report that Mac-1 on myeloid cells is key to disease development. Our data reveal that myeloid-specific Mac-1 significantly increases EAE severity and hinders disease regression. Loss of Mac-1 increases Gr-1

Indexed as

Autoimmune DiseasesEncephalomyelitis, Autoimmune, ExperimentalImmune ToleranceMacrophage-1 AntigenNitric OxideSignal TransductionAnimalsDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, KnockoutMonocytesMultiple SclerosisMacrophage-1 AntigenNitric Oxide

Identifiers

PMID40344054
PMCPMC12063669

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.