ArticleProceedings of the National Academy of Sciences of the United States of America2025
Architecture of
Michael K Fenwick, Stephen J Mayclin, Steve Seibold, Amy E DeRocher, Sandhya Subramanian, Isabelle Q Phan, David M Dranow, Donald D Lorimer, Ariel B Abramov, Ryan Choi and 11 more
Abstract read
In one paragraphArticle in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
21 authors.
Michael K FenwickSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0001-5066-4962 Stephen J MayclinSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Steve SeiboldSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Amy E DeRocherSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0003-1205-7920 Sandhya SubramanianSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Isabelle Q PhanSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0001-6873-3401 David M DranowSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Donald D LorimerSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Ariel B AbramovSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Ryan ChoiSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Stephen Nakazawa HewittSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Thomas E EdwardsSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0002-0474-8003 Aimee C SoeMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Susan E TsutakawaMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-4918-4571 Scott LovellSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0002-3215-4472 Peter J MylerSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.ORCID 0000-0002-0056-0513 Bart L StakerSeattle Structural Genomics Center for Infectious Disease, Seattle Children's Research Institute, Seattle, WA 98109.
Funding
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MCenters for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7MAn Eiger2 XE 9M detector for the NYSBC-operated NYX beamline at NSLS-IIS10OD030394 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI BATTAILE, KEVIN P · 2021 to 2021
$1.8MA Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998kHHS | NIH (NIH) S10OD018483NIAID NIH HHS 75N93022C00036NIAID NIH HHS HHSN272200700057CNIAID NIH HHS HHSN272201200025CNIAID NIH HHS HHSN272201700059CNIGMS NIH HHS P30 GM124169NIH HHS S10 OD018483NIH HHS S10 OD030394
6 · The paper itselfAbstract
The aminoacyl-tRNA synthetases (AaRSs) are an ancient family of structurally diverse enzymes that are divided into two major classes. The functionalities of most AaRSs are inextricably linked to their oligomeric states. While GluRSs were previously classified as monomers, the current investigation reveals that the form expressed in
Indexed as
Amino Acyl-tRNA SynthetasesBacterial ProteinsGlutamate-tRNA LigasePseudomonas aeruginosaAnticodonBinding SitesCatalytic DomainModels, MolecularProtein MultimerizationRNA, TransferAmino Acyl-tRNA SynthetasesAnticodonBacterial ProteinsGlutamate-tRNA LigaseRNA, Transferaminoacyl-tRNA synthetaseoligomerizationprotein translation
Identifiers
PMID40343997
PMCPMC12088422
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