Evidence map›Paper›PMID 40343995›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate.

Jinling Han, Meichen Zhang, Jiakun Ge, Zhihua Ji, Jianyi Zhao, Yinchao Hu, Chunshuang Li, Yaoyao Xue, Xining Li, Haiwang Zhao and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. 8-Oxoguanine: A Lesion, an Epigenetic Mark, or a Molecular Signal?International journal of molecular sciences · 2025
    Review
  3. Review
  4. OGG1 augments the transcriptional activation ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jinling HanDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.ORCID 0009-0003-0437-3349
Meichen ZhangDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Jiakun GeDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Zhihua JiDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Jianyi ZhaoDepartment of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun 130061, China.
Yinchao HuDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Chunshuang LiDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Yaoyao XueDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Xining LiDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Haiwang ZhaoDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Zixu CuiDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Miaomiao TianDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Xu ZhengDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.ORCID 0000-0002-6326-9248
Dapeng WangLung Transplant Center, Department of Respiratory Medicine, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu 214023, China.
Jing WangDepartment of Respiratory Medicine, China-Japan Union Hospital of Jilin University, Changchun 130061, China.
Min WeiDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.
Zsolt RadakResearch Center for Molecular Exercise Science, Institute of Sport Science, University of Physical Education, Budapest H-1123, Hungary.
Yusaku NakabeppuDivision of Neurofunctional Genomics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-6739-242X
Istvan BoldoghDepartment of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, TX 77555.
Xueqing BaDivision of Human Health, Key Laboratory of Molecular Epigenetics of Ministry of Education, Northeast Normal University, Changchun 130024, China.ORCID 0000-0002-1075-5496

Funding

Virus, Tissue Culture and ImmunoassayP01AI062885 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI CASOLA, ANTONELLA · 2005 to 2022
$23.9M
Education Department of Jilin Province () JJKH20250323KJHHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI062885MOST | National Natural Science Foundation of China (NSFC) 31970686MOST | National Natural Science Foundation of China (NSFC) 32170591| Natural Science Foundation of Jilin Province (Jilin Natural Science Foundation) 20220203147SFNIAID NIH HHS P01 AI062885
6 · The paper itself

Abstract

8-oxoguanine (8-oxoGua) is one of the most frequent forms of oxidative DNA base lesions, repaired by 8-oxoguanine DNA glycosylase 1 (OGG1) via base excision repair (BER) pathway to maintain genome fidelity. The human allelic variant

Indexed as

DNADNA GlycosylasesInflammationAnimalsDNA DamageDNA RepairGuanineHumansMiceNF-kappa BPhosphorylationReactive Oxygen Species8-hydroxyguanineDNADNA GlycosylasesGuanineNF-kappa BOgg1 protein, mouseoxoguanine glycosylase 1, humanReactive Oxygen Species8-oxoguanine DNA glycosylase-1 (OGG1)inflammatory gene expressionlung injuryOGG1S326Csingle nucleotide polymorphism

Identifiers

PMID40343995
PMCPMC12088383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.