Evidence map›Paper›PMID 40343971›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

MALT1 inhibitor MI-2 induces ferroptosis by direct targeting of GPX4.

Eikan Mishima, Thomas J O'Neill, Kai P Hoefig, Deng Chen, Gesine Behrens, Bernhard Henkelmann, Junya Ito, Kiyotaka Nakagawa, Vigo Heissmeyer, Marcus Conrad and 1 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Reply to Mishima et al.: MALT1 modulates GPX4 expression by regulating its stability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eikan Mishima *Institute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.
Thomas J O'Neill *Research Unit Signaling and Translation, Group Signaling and Immunity, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.ORCID 0000-0003-2253-3118
Kai P HoefigResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Munich, Munich 81377, Germany.
Deng ChenInstitute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.
Gesine BehrensResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Munich, Munich 81377, Germany.
Bernhard HenkelmannInstitute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.
Junya ItoLaboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan.
Kiyotaka NakagawaLaboratory of Food Function Analysis, Graduate School of Agricultural Science, Tohoku University, Sendai 980-8572, Japan.
Vigo HeissmeyerResearch Unit Molecular Immune Regulation, Molecular Targets and Therapeutics Center, Helmholtz Munich, Munich 81377, Germany.
Marcus ConradInstitute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.ORCID 0000-0003-1140-5612
Daniel KrappmannResearch Unit Signaling and Translation, Group Signaling and Immunity, Molecular Targets and Therapeutics Center, Helmholtz Munich, Neuherberg 85764, Germany.ORCID 0000-0001-7640-3234

Funding

Deutsche Forschungsgemeinschaft (DFG) 452881907Deutsche Krebshilfe (German Cancer Aid) 70115440EC | European Research Council (ERC) 884754Wilhelm Sander-Stiftung (Wilhelm Sander Foundation) 2018.082.3
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40343971
PMCPMC12107143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.