ArticleAmerican journal of physiology. Cell physiology2025
Insulin potentiates mechanical responses in small dorsal root ganglion neurons by increasing the sensitization of TRPV4 channels.
Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Transient Receptor Potential Vanilloid 4 (TRPV4) in the Human Carotid Body.International journal of molecular sciences · 2025Article
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9 authors.
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Abstract
We have previously reported that insulin potentiates the response to mechanical stimuli in small dorsal root ganglion (DRG) neurons. However, the mechanisms underlying the insulin-induced potentiated responsiveness to mechanical stimulation in sensory neurons remain unclear. Transient receptor potential vanilloid 4 (TRPV4) is expressed as a mechanosensitive channel in DRG neurons and is activated by mechanical stimuli. We therefore hypothesized that insulin augments the response to mechanical stimulation in small DRG neurons by enhancing sensitization of TRPV4 channels. Colocalization of TRPV4, insulin receptor (IR), and the C-fiber marker peripherin in small DRG neurons was evaluated by immunofluorescence, demonstrating that 53 ± 10% of TRPV4-positive small DRG neurons were colocalized with IR and peripherin. In in vitro whole cell patch clamp recordings from cultured DRG neurons, mechanically activated currents were significantly increased 5 min after the application of insulin (
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