ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Integrating Catalysis and Analysis: Accelerated Asymmetric Reaction Development With a Multitasking Reactivity Umpolung/Chiroptical Reporter Auxiliary.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Chiral Analysis for High-Throughput Reaction Screening: Recent Advances in Accelerating Asymmetric Catalysis Discovery.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
High-throughput asymmetric reaction development of an organocatalytic Michael addition is achieved by using a readily available isatin molecule as an amine protecting group, reagent for reactivity Umpolung, and as a chiroptical yield and enantioselectivity reporter. The use of UV and circular dichroism inductions allows on-the-fly, chromatography-free parallel screening of a hundred reaction conditions to identify a catalytic procedure that converts a primary amine to either enantiomer of an a-branched chiral product in excellent yields and ee's. The isatin is recyclable and can be quantitatively recovered if desired. This case study shows how chiroptical high-throughput screening with a multitasking reagent can increase method development speed and reduce cost and waste compared to traditional reaction optimization workflows by streamlining the analysis of small-scale reaction setups and eliminating time-consuming work-up protocols.
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Registered trials
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