Trial reportClinical rheumatology2025
Comparison of intra-articular ozone and steroid injection in patients with adhesive capsulitis.
Trial report in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Efficacy of Oxygen-Ozone Therapy for Shoulder Disorders: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Reply to letter to editor regarding "Comparison of intra-articular ozone and steroid injection in patients with adhesive capsulitis".Clinical rheumatology · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAdhesive capsulitis is a disease characterized by a significant decrease in the active and passive range of motion(ROM) of the glenohumeral joint along with pain. Ozone therapy has demonstrated promising results in treating various diseases. This study aims to compare the efficacy of intraarticular ozone administration with steroid injection in treating adhesive capsulitis.
methodsOur study is a single-blind, prospective and comparative clinical trial. The study included 40 patients who were randomly assigned to one of two groups. The study group received 8 sessions of intra-articular ozone injection under ultrasound guidance, while the control group received a single intra-articular steroid injection. Patient evaluations were conducted before treatment, as well as 4 and 12 weeks after treatment. The study utilized three evaluation scales: the visual analog scale(VAS) for pain, the Shoulder Pain and Disability Index (SPADI), and ROM measurements.
resultsBoth treatment groups demonstrated a statistically significant improvement in range of motion, SPADI, and VAS scores compared to their values at baseline and weeks 4 and 12. However, no statistically significant difference was found between the two groups in the magnitude of improvement across these outcomes.
conclusionThe study results demonstrate that ozone injection repeated eight times led to improvements in pain, function, and range of motion that were not statistically different from those observed with a single corticosteroid injection in treating adhesive capsulitis. Although the study was not designed as a non-inferiority trial, the findings suggest that intra-articular ozone administration may be a potentially beneficial alternative treatment option. Key Points • This study demonstrates that intra-articular ozone (O
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