SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Intra-articular hyaluronic acid injections for hip osteoarthritis: a level I systematic review.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of Clinical Efficiency and Safety Between Intra-Articular Injection of Platelet-Rich Plasma and Hyaluronic Acid for Hip Osteoarthritis: A Systematic Review and Meta-Analysis.Pain research & management · 2026Pooled it
- Osteoarthritis: Epidemiology, Diagnosis, and Treatment.MedComm · 2026Review
- Association Between Intra-Articular Hyaluronic Acid Injections and Reduction in Analgesic Prescriptions in Knee Osteoarthritis: A Real-World Study from German Outpatient Care.Journal of clinical medicine · 2026Article
- EUROVISCO Recommendations for the Use of Viscosupplementation with Hyaluronic Acid in the Management of Hip Osteoarthritis.Cartilage · 2026Article
- Intra-articular hyaluronic acid (viscosupplementation) for osteoarthritis: is it effective?Australian prescriber · 2026Review
- RNA-Seq of Gingival Fibroblasts Grown on Collagen Membranes and Hyaluronic Acid.Journal of functional biomaterials · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe present systematic review investigated the efficacy of intra-articular hyaluronic acid (HA) viscosupplementation for hip osteoarthritis (OA) in patient-reported outcome measures (PROMs) and whether different molecular weights of HA are associated with different outcomes.
methodsThis study was conducted according to the 2020 PRISMA statement. In January 2025, PubMed, Web of Science, Google Scholar, and Embase were accessed. All the randomised controlled trials (RCTs) evaluating the efficacy of intra-articular HA injections in the hip for OA were included.
resultsNine hundred and eighty-two patients (56% women, mean age 62.2 ± 4.0 years, mean follow-up 6.4 ± 2.7 months, mean BMI 27.5 ± 2.1 kg/m
conclusionIntra-articular injections of HA effectively reduce knee OA symptoms. Moreover, HMW HA performs better than MMW HA at a mean of 4-6 months of follow-up. LEVEL OF EVIDENCE: Level I, systematic review of RCTs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.