ArticleBrain and behavior2025
Safflower Yellow Pigment Alleviates Cerebral Ischemia-Reperfusion Injury via Protein Nitration and Oxidative Modulation.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveWe seek to investigate the efficacy of safflower yellow pigment in mitigating cerebral ischemia-reperfusion injury by examining its effects on protein nitration and oxidative modification.
methodsA total of 160 patients with acute ischemic stroke admitted to the department of neurology of Xingtai people's hospital were included in this study. This study was a retrospective study. Patients were divided into the control group (n = 80) and the observation group (n = 80) according to whether safflower yellow pigment was used. The control group received conventional treatment, and the observation group received safflower yellow pigment.
resultsBaseline characteristics did not significantly differ between the two groups (p > 0.05). Serum nitrosine levels were lower in the observation group compared to the control group after 24 h and one week of treatment (p < 0.05). Similarly, serum carbonylated protein levels were lower in the observation group after 24 h and one week of treatment (p < 0.05). The observation group exhibited lower NIHSS and modified rankin scale (mRS) scores, reduced cerebral ischemic area. Furthermore, levels of malondialdehyde (MDA), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) were lower, while superoxide dismutase (SOD) activity was higher in the observation group compared to the control group after one week of treatment (p < 0.05).
conclusionSafflower yellow pigment demonstrates significant neuroprotective effects in patients with cerebral ischemia-reperfusion injury by reducing protein oxidation and nitration, improving neurological function, reducing cerebral ischemic area, and attenuating oxidative stress and inflammation.
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