Evidence map›Paper›PMID 40343345›Full record

ArticleResearch square2025

Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures.

Fatemeh Azari, Anne M Robertson, Yasutaka Tobe, Paul N Watton, Lori A Birder, Naoki Yoshimura, Kanako Matsuoka, Christopher Hardin, Simon Watkins

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Fatemeh AzariDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, PA, U.S.A.
Anne M RobertsonDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, PA, U.S.A.
Yasutaka TobeDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, PA, U.S.A.
Paul N WattonDepartment of Mechanical Engineering and Materials Science, University of Pittsburgh, PA, U.S.A.
Lori A BirderDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Naoki YoshimuraDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Kanako MatsuokaDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, U.S.A.
Christopher HardinDepartment of Nutrition and Exercise Physiology, University of Missouri School of Medicine, Columbia, MO, U.S.A.
Simon WatkinsCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, U.S.A.

Funding

A Digital Twin for Designing Bladder Treatment informed by Bladder Outlet Obstruction Mechanobiology (BOOM)R01DK133434 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anne Marie Robertson, Paul Watton · 2023 to 2026
$3.2M
Bladder Mucosal Dysfunction During AgingR01AG056944 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, BIRDER, LORI A · 2018 to 2022
$3.2M
NIA NIH HHS R01 AG056944NIDDK NIH HHS R01 DK133434
6 · The paper itself

Abstract

The high compliance of the urinary bladder during filling is essential for its proper function, enabling it to accommodate significant volumetric increases with minimal rise in transmural pressure. This study aimed to elucidate the physical mechanisms underlying this phenomenon by analyzing the ex vivo filling process in rat from a fully voided state to complete distension, without preconditioning, using three complementary imaging modalities. High-resolution micro-CT at 10.8

Indexed as

ComplianceInflation testingMicro-CTMultiphoton (MPM) imagingUrinary bladder wall

Identifiers

PMID40343345
PMCPMC12060976

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.